Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan.
Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association, 2-3-8, Tosabori, Nishi-ku, Osaka 550-0001, Japan.
Environ Int. 2016 Nov;96:16-23. doi: 10.1016/j.envint.2016.08.025. Epub 2016 Aug 31.
Phthalates are widely used as plasticizers in household products. Several studies have reported an association between phthalate exposure and an increased risk of allergies. The present study estimated phthalate exposure in children aged 6-12years and assessed potential correlations with allergies. House dust samples were collected from floors and multi-surface objects >35cm above the floor. Urine samples were collected from the first morning void of the day. Daily phthalate intake (DI and DI) was estimated using both house dust and urinary metabolite concentrations. Exposure to di-2-ethylhexyl phthalate (DEHP) in floor dust was associated with parental-reported rhino-conjunctivitis. After stratification by gender, this trend was found to only occur in boys. Furthermore, urinary mono-isobutyl phthalate was inversely associated with parental-reported wheeze in boys. DI of benzyl butyl phthalate (BBzP) and DEHP were significantly correlated with DI_BBzP and DI_DEHP, respectively. These correlations were stronger with floor than with multi-surface dust. Our results suggest that, among Japanese children, house dust from low surfaces, such as living room floors, might play a meaningful role in the indoor environmental exposure pathway for BBzP and DEHP.
邻苯二甲酸酯作为增塑剂广泛应用于家用产品中。一些研究报告指出，邻苯二甲酸酯暴露与过敏风险增加之间存在关联。本研究估计了 6-12 岁儿童的邻苯二甲酸酯暴露水平，并评估了与过敏的潜在相关性。从地板和高于地板 35 厘米以上的多表面物体上收集室内灰尘样本。从当天早晨第一次排空的尿液中收集尿液样本。使用室内灰尘和尿液代谢物浓度来估算每日邻苯二甲酸酯摄入量（DI 和 DI）。地板灰尘中邻苯二甲酸二（2-乙基己基）酯（DEHP）的暴露与父母报告的鼻结膜炎有关。按性别分层后，发现这一趋势仅在男孩中发生。此外，尿液中单异丁基邻苯二甲酸酯与男孩父母报告的喘息呈负相关。邻苯二甲酸丁基苄基酯（BBzP）和 DEHP 的 DI 与 DI_BBzP 和 DI_DEHP 分别呈显著相关。与多表面灰尘相比，这种相关性在地板上更强。我们的研究结果表明，在日本儿童中，来自低表面（如客厅地板）的室内灰尘可能在 BBzP 和 DEHP 的室内环境暴露途径中发挥重要作用。
