Niknam Farid, Azadi Amir, Barzegar Alireza, Faridi Pouya, Tanideh Nader, Zarshenas Mohammad M
Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box: 71345-1583, Shiraz, Iran.
Curr Drug Discov Technol. 2016;13(4):199-210. doi: 10.2174/1570163813666160905115325.
Persian or Russian olive (Elaeagnus angustifolia L.), from the family Elaeagnaceae, is a nitrogen-fixing thorny shrub extensively used in traditional medicine to alleviate pain and treat rheumatoid arthritis, osteoarthritis, gastrointestinal problems, fever, and asthma. The current review has tried to give a concise overview of the phytochemistry and pharmacological properties of the plant from published data. Accordingly, published English literatures on Elaeagnus angustifolia were gathered from popular databases such as PubMed, Scopus, Web of Science, and ScienceDirect up to 31 December 2015. In accordance with traditional and ethnopharmacological uses, different extracts of E. angustifolia have been known for their antioxidant, anti-inflammatory, anti-nociceptive, antimicrobial, muscle relaxant, anti-ulcer and wound-healing capabilities. Additionally, cardioprotective, antitumor and anti-mutagenic effects of the herb have been demonstrated by current assessments. Despite numerous experimental studies, there is a notable lack of profound and comprehensive clinical trials as well as critical research on E. angustifolia toxicity and teratogenicity. With reference to various pharmacological effects based on experimental and animal investigation, it is worthy to mention a frame for respective clinical studies in further studies.
沙枣（胡颓子科沙枣属植物沙枣）是一种固氮多刺灌木，在传统医学中被广泛用于缓解疼痛以及治疗类风湿性关节炎、骨关节炎、胃肠道问题、发热和哮喘。本综述试图根据已发表的数据对该植物的植物化学和药理特性进行简要概述。因此，截至2015年12月31日，从PubMed、Scopus、科学引文索引和ScienceDirect等知名数据库收集了关于沙枣的已发表英文文献。根据传统和民族药理学用途，沙枣的不同提取物以其抗氧化、抗炎、抗伤害感受、抗菌、肌肉松弛、抗溃疡和伤口愈合能力而闻名。此外，目前的评估已经证实了该草药的心脏保护、抗肿瘤和抗诱变作用。尽管有大量的实验研究，但关于沙枣毒性和致畸性的深入全面的临床试验以及关键研究仍明显不足。参照基于实验和动物研究的各种药理作用，值得在进一步研究中提及各自临床研究的框架。
