Chang L J, Dienstag J, Ganem D, Varmus H
Department of Microbiology, University of California Medical Center, San Francisco 94143.
Hepatology. 1989 Sep;10(3):332-5. doi: 10.1002/hep.1840100314.
By the use of a truncated recombinant hepatitis B virus polymerase antigen, we have characterized a series of patient sera for anti-hepatitis B virus polymerase antibodies. Seven of 54 (13%) had antipolymerase antibodies detectable by Western blot analysis, and no close correlation was apparent between the disease status and patient's immune response against hepatitis B virus polymerase antigen. Our results indicate that serologic responses to the viral polymerase are demonstrable but suggest that such antibodies are not likely to be clinically useful as diagnostic or prognostic markers of infection.
通过使用截短的重组乙型肝炎病毒聚合酶抗原，我们对一系列患者血清中的抗乙型肝炎病毒聚合酶抗体进行了鉴定。54例患者中有7例（13%）通过蛋白质印迹分析可检测到抗聚合酶抗体，疾病状态与患者针对乙型肝炎病毒聚合酶抗原的免疫反应之间未显示出明显的相关性。我们的结果表明，对病毒聚合酶的血清学反应是可证实的，但提示此类抗体不太可能作为感染的诊断或预后标志物在临床上发挥作用。
