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在未服用药物的阿尔茨海默病患者中，异常的脑干形态测量与睡眠障碍相关。

Aberrant brain stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease.

作者信息

Lee Ji Han, Jung Won Sang, Choi Woo Hee, Lim Hyun Kook

机构信息

Washington University in St Louis, St Louis, MO, USA.

Department of Radiology.

出版信息

Neuropsychiatr Dis Treat. 2016 Aug 23;12:2089-93. doi: 10.2147/NDT.S114383. eCollection 2016.

DOI:10.2147/NDT.S114383
PMID:27601903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5003099/
Abstract

OBJECTIVE

Among patients with Alzheimer's disease (AD), sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.

MATERIALS AND METHODS

In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.

RESULTS

Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.

CONCLUSION

This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings.

摘要

目的

在阿尔茨海默病（AD）患者中，睡眠障碍是常见且严重的非认知症状。先前对AD患者的研究已发现脑干存在变形，这可能在睡眠调节中起重要作用。本研究的目的是进一步探究AD患者睡眠障碍与脑干形态改变之间的关系。

材料与方法

在44例AD患者和40例健康老年对照者中，使用神经精神科量表睡眠分量表测量睡眠障碍。我们采用基于磁共振成像的自动分割工具来研究睡眠障碍与脑干形态变化之间的关系。

结果

对AD受试者数据的分析显示，神经精神科量表睡眠分量表评分与脑干左后外侧区域的结构改变以及脑干标准化体积之间存在显著相关性。此外，AD组和对照组之间在脑干后部形态上存在显著的组间差异。

结论

本研究首次分析了AD患者睡眠障碍与脑干形态之间的关联。与先前的研究结果一致，本研究支持脑干结构异常可能是AD相关睡眠障碍的重要神经生物学机制这一可能性。需要进一步的纵向研究来证实这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/086d/5003099/270b008a44c8/ndt-12-2089Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/086d/5003099/6281b1c1eaf6/ndt-12-2089Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/086d/5003099/270b008a44c8/ndt-12-2089Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/086d/5003099/6281b1c1eaf6/ndt-12-2089Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/086d/5003099/270b008a44c8/ndt-12-2089Fig2.jpg

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