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锶和锂的单掺杂和双掺杂对生物活性玻璃支架体内生物性能的影响。

Influence of single and binary doping of strontium and lithium on in vivo biological properties of bioactive glass scaffolds.

机构信息

Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India.

Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata, India.

出版信息

Sci Rep. 2016 Sep 8;6:32964. doi: 10.1038/srep32964.

DOI:10.1038/srep32964
PMID:27604654
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5015095/
Abstract

Effects of strontium and lithium ion doping on the biological properties of bioactive glass (BAG) porous scaffolds have been checked in vitro and in vivo. BAG scaffolds were prepared by conventional glass melting route and subsequently, scaffolds were produced by evaporation of fugitive pore formers. After thorough physico-chemical and in vitro cell characterization, scaffolds were used for pre-clinical study. Soft and hard tissue formation in a rabbit femoral defect model after 2 and 4 months, were assessed using different tools. Histological observations showed excellent osseous tissue formation in Sr and Li + Sr scaffolds and moderate bone regeneration in Li scaffolds. Fluorochrome labeling studies showed wide regions of new bone formation in Sr and Li + Sr doped samples as compared to Li doped samples. SEM revealed abundant collagenous network and minimal or no interfacial gap between bone and implant in Sr and Li + Sr doped samples compared to Li doped samples. Micro CT of Li + Sr samples showed highest degree of peripheral cancellous tissue formation on periphery and cortical tissues inside implanted samples and vascularity among four compositions. Our findings suggest that addition of Sr and/or Li alters physico-chemical properties of BAG and promotes early stage in vivo osseointegration and bone remodeling that may offer new insight in bone tissue engineering.

摘要

锶和锂离子掺杂对生物活性玻璃（BAG）多孔支架的生物学性能的影响已在体外和体内进行了检查。BAG 支架通过常规的玻璃熔融路线制备，然后通过挥发逃逸孔形成剂来生产支架。在进行彻底的物理化学和体外细胞特性分析后，支架被用于临床前研究。在 2 个月和 4 个月后，使用不同的工具评估了在兔股骨缺损模型中软、硬组织的形成情况。组织学观察显示，Sr 和 Li+Sr 支架中的骨组织形成良好，Li 支架中的骨再生中等。荧光标记研究表明，与 Li 掺杂的样品相比，Sr 和 Li+Sr 掺杂的样品中有广泛的新骨形成区域。SEM 显示，与 Li 掺杂的样品相比，Sr 和 Li+Sr 掺杂的样品中胶原纤维网络丰富，骨与植入物之间的界面间隙最小或没有。Li+Sr 样品的微 CT 显示，在四种成分中，周边松质骨组织的形成程度最高，植入样本内部的皮质组织和血管化程度也最高。我们的研究结果表明，Sr 和/或 Li 的添加改变了 BAG 的物理化学性质，并促进了体内早期的骨整合和骨重塑，这可能为骨组织工程提供新的见解。

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