Santosh Paramala J, Bell Laura, Fiori Federico, Singh Jatinder
1 Department of Child Psychiatry, King's College London , London, United Kingdom .
2 Centre for Interventional Pediatric Psychopharmacology and Rare Diseases (CIPPRD) , South London and Maudsley NHS Foundation Trust, London, United Kingdom .
J Child Adolesc Psychopharmacol. 2017 Aug;27(6):546-554. doi: 10.1089/cap.2015.0247. Epub 2016 Sep 8.
Antipsychotic (ATP) prescription rates have increased in children and adolescents despite concern regarding the safety and effectiveness of ATP usage in community populations. Rising safety concerns and uncertainty regarding ATP effectiveness in children stress the need for improvement in routine clinical outcome monitoring and research. Due to the growing number of children exposed to atypical ATPs, studies assessing the risk/benefit ratio of administering ATPs in this age group-especially in off-label conditions-become of high importance. The Centre for Interventional Pediatric Psychopharmacology and Rare Diseases (CIPPRD) uses a suite of instruments to monitor outcomes using the web-based HealthTracker™, a health monitoring platform. The HealthTracker allows for capture of symptoms, side effects, quality of life, patient experience, and lifetime response to individualized treatments using a multi-informant multimodal methodology. It enables the tracking of ongoing medical treatments and assists in shared treatment decision-making, longitudinal patient centered outcome monitoring, and helps optimize care. An example of its use in the CIPPRD is provided to demonstrate how it can be used for ATP-related outcome monitoring in complex neurodisability within routine clinical practice.
尽管人们对社区人群使用抗精神病药物（ATP）的安全性和有效性存在担忧，但儿童和青少年中ATP的处方率仍在上升。对ATP安全性的担忧日益增加，以及其在儿童中的有效性存在不确定性，这凸显了改善常规临床结果监测和研究的必要性。由于接触非典型ATP的儿童数量不断增加，评估在该年龄组使用ATP的风险/收益比的研究变得尤为重要，特别是在非标签使用的情况下。介入性儿科精神药理学和罕见病中心（CIPPRD）使用一套工具，通过基于网络的健康追踪平台HealthTracker™来监测结果。HealthTracker允许使用多信息提供者多模式方法捕捉症状、副作用、生活质量、患者体验以及对个体化治疗的终生反应。它能够跟踪正在进行的医疗治疗，并协助进行共同的治疗决策、以患者为中心的纵向结果监测，并有助于优化护理。文中提供了CIPPRD使用该平台的一个例子，以展示它如何在常规临床实践中用于复杂神经残疾中与ATP相关的结果监测。
