Martin L
J Reprod Fertil. 1979 Jan;55(1):135-9. doi: 10.1530/jrf.0.0550135.
Intrauterine instillations of oil or saline distended the uterus in ovariectomized mice treated with progesterone + oestrogen to sensitize the uterus to a decidualizing stimulus. Saline does not induce decidualization, and therefore uterine distension per se is not the trigger to decidual induction. Oil induces decidualization, but does not involve gross damage to the epithelium, penetration of oil into the stroma or release of epithelial lipid into the stroma. Instillation (oil, saline or sham) induced a contraction of the circular muscles along the length of the uterus which closed the uterine lumen, expelled most of the oil and located the remainder primarily in the antimesometrial cleft of the lumen. Progesterone inhibited longitudinal muscle contraction and facilitated circular muscle contraction. These effects are discussed in relation to the spacing and implantation of blastocysts.
在用孕酮 + 雌激素处理的去卵巢小鼠中，向子宫内注入油或盐水可使子宫扩张，从而使子宫对蜕膜化刺激敏感。盐水不会诱导蜕膜化，因此子宫扩张本身并非诱导蜕膜化的触发因素。油可诱导蜕膜化，但不涉及对上皮的严重损伤、油渗透到基质中或上皮脂质释放到基质中。注入（油、盐水或假注入）会引起子宫全长环形肌的收缩，从而封闭子宫腔，排出大部分油，并将其余部分主要定位在子宫腔的反系膜裂中。孕酮抑制纵向肌收缩并促进环形肌收缩。结合胚泡的间距和着床对这些作用进行了讨论。
