Efthymiou Georgios, Dardiotis Efthymios, Liaskos Christos, Marou Emmanouela, Tsimourtou Vana, Scheper Thomas, Meyer Wolfgang, Daponte Alexandros, Sakkas Lazaros I, Hadjigeorgiou Georgios, Bogdanos Dimitrios P
Cellular Immunotherapy & Molecular Immunodiagnostics, Biomedical Section, Centre for Research and Technology-Hellas (CERTH), Institute for Research and Technology-Thessaly (IRETETH), 41222 Larissa, Greece; Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 40500 Larissa, Greece; Department of Rheumatology, University General Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, 41110 Larissa, Greece.
Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 40500 Larissa, Greece.
J Neuroimmunol. 2016 Sep 15;298:19-23. doi: 10.1016/j.jneuroim.2016.06.009. Epub 2016 Jun 23.
In view of published data suggesting that Helicobacter pylori (Hp) is a trigger of multiple sclerosis (MS), we assessed anti-heat shock protein 60 (hsp60)Hp antibody reactivity in 129 MS patients and 48 demograpically-matched healthy controls (HCs). Anti-Hp antibodies by ELISA were more elevated in MS than HCs but did not differ between different MS phenotypes. All anti-Hp-positive MS sera, irrespectively of their clinical phenotype, were anti-anti-hsp60 positive. Anti-hsp60 Hp seropositivity correlated with age at disease onset. In conclusion, anti-hsp60 Hp antibodies are present in all anti-Hp positive MS patients, and their relevance to disease pathogenesis is questionable.
鉴于已发表的数据表明幽门螺杆菌（Hp）是多发性硬化症（MS）的一个触发因素，我们评估了129例MS患者和48例人口统计学匹配的健康对照者（HCs）中抗热休克蛋白60（hsp60）Hp抗体的反应性。通过酶联免疫吸附测定法检测的抗Hp抗体在MS患者中比HCs更高，但在不同的MS表型之间没有差异。所有抗Hp阳性的MS血清，无论其临床表型如何，均为抗抗hsp60阳性。抗hsp60 Hp血清阳性与疾病发病年龄相关。总之，所有抗Hp阳性的MS患者中均存在抗hsp60 Hp抗体，其与疾病发病机制的相关性值得怀疑。
