利托那韦与靶心样黄斑病变：病例报告
Ritonavir and bull's eye maculopathy: case report.
作者信息
Pinto Rita, Vila-Franca Marta, Oliveira Afonso Cláudia, Ornelas Conceição, Santos Luisa
机构信息
Instituto de Oftalmologia Dr Gama Pinto, Lisboa, Portugal.
Departamento de Infecciologia do Hospital de Santa Maria, Lisboa, Portugal.
出版信息
GMS Ophthalmol Cases. 2013 Jan 10;3:Doc01. doi: 10.3205/oc000011. eCollection 2013.
OBJECTIVE
To report on a case of retinal pigment epithelium (RPE) toxicity apparently associated with ritonavir.
METHODS
We describe a case of gradual-onset blurry vision in both eyes in a 30-year-old HIV-positive male on Highly-Active Antiretroviral Therapy (HAART) including ritonavir Results: The patient presented with a visual acuity of 3/10 in each eye, and fundoscopy revealed paracentral pigment mottling. Computerized perimetry showed a ring-scotoma in both eyes. Fluorescein angiography revealed an anular RPE defect in both eyes, congruent with hyperautofluorescent changes on autofluorescence imaging. Full-field ERG was normal.
CONCLUSIONS
Since ritonavir has previously been linked with toxicity to the RPE, we consider this report as further evidence of this association.
目的
报告一例明显与利托那韦相关的视网膜色素上皮（RPE）毒性病例。
方法
我们描述了一名30岁接受包括利托那韦在内的高效抗逆转录病毒疗法（HAART）的HIV阳性男性双眼逐渐出现视力模糊的病例。结果：患者双眼视力均为3/10，眼底镜检查发现旁中心色素斑驳。电脑视野检查显示双眼环形暗点。荧光素血管造影显示双眼环形RPE缺损，与自发荧光成像上的高自发荧光变化一致。全视野视网膜电图正常。
结论
由于利托那韦此前已被认为与RPE毒性有关，我们认为本报告是这种关联的进一步证据。
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