Jones Peter, Kalra Gagan, Al-Sheikh Mayss, Chhablani Jay
UPMC Vision Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Clin Exp Ophthalmol. 2024 Dec;52(9):1003-1015. doi: 10.1111/ceo.14461. Epub 2024 Dec 3.
Hydroxychloroquine (HCQ) retinal toxicity is an important entity that can be challenging to differentiate from its mimickers. Bull's eye maculopathy is the classical presentation of HCQ retinopathy; however, its differential includes several drug-related retinal toxicities, inherited retinal disorders, and systemic conditions with associated retinopathies. Given the similarities in clinical presentation, imaging findings, and other diagnostic data, it can be quite challenging for all but the retina specialists to successfully identify retinal toxicity from HCQ. This review summarises HCQ retinopathy and its mimickers of with a special emphasis on key clinical and ancillary distinctions that can help comprehensive ophthalmologists and primary care offices in clenching this diagnosis.
羟氯喹啉（HCQ）视网膜毒性是一种重要的病症，很难与类似病症相区分。靶心状黄斑病变是HCQ视网膜病变的典型表现；然而，其鉴别诊断包括几种与药物相关的视网膜毒性、遗传性视网膜疾病以及伴有视网膜病变的全身性疾病。鉴于临床表现、影像学检查结果及其他诊断数据存在相似之处，除视网膜专科医生外，其他医生要成功识别HCQ所致的视网膜毒性颇具挑战。本综述总结了HCQ视网膜病变及其类似病症，特别强调了关键的临床和辅助鉴别要点，这有助于综合眼科医生和初级保健机构做出这一诊断。
