2012 - 2013年泰国人类冠状病毒的分子流行病学及特征分析
Molecular epidemiology and characterization of human coronavirus in Thailand, 2012-2013.
作者信息
Soonnarong Rapeepun, Thongpan Ilada, Payungporn Sunchai, Vuthitanachot Chanpim, Vuthitanachot Viboonsuk, Vichiwattana Preeyaporn, Vongpunsawad Sompong, Poovorawan Yong
机构信息
Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
Springerplus. 2016 Aug 26;5(1):1420. doi: 10.1186/s40064-016-3101-9. eCollection 2016.
BACKGROUND
Coronavirus causes respiratory infections in humans. To determine the prevalence of human coronavirus (HCoV) infection among patients with influenza-like illness, 5833 clinical samples from nasopharyngeal swabs and aspirates collected between January 2012 and December 2013 were examined.
RESULTS
HCoV was found in 46 (0.79 %) samples. There were 19 (0.32 %) HCoV-HKU1, 19 (0.32 %) HCoV-NL63, 5 (0.09 %) HCoV-229E, and 3 (0.05 %) HCoV-OC43. None of the sample tested positive for MERS-CoV. The majority (54 %) of the HCoV-positive patients were between the ages of 0 and 5 years. HCoV was detected throughout the 2-year period and generally peaked from May to October, which coincided with the rainy season. Phylogenetic trees based on the alignment of the spike (S) gene sequences suggest an emergence of a new clade for HCoV-229E.
CONCLUSIONS
The data in this study provide an insight into the prevalence of the recent circulating HCoVs in the region.
背景
冠状病毒可导致人类呼吸道感染。为确定流感样疾病患者中人类冠状病毒（HCoV）感染的流行情况，对2012年1月至2013年12月期间收集的5833份来自鼻咽拭子和抽吸物的临床样本进行了检测。
结果
在46份（0.79%）样本中发现了HCoV。其中有19份（0.32%）HCoV-HKU1、19份（0.32%）HCoV-NL63、5份（0.09%）HCoV-229E和3份（0.05%）HCoV-OC43。没有样本检测出中东呼吸综合征冠状病毒（MERS-CoV）呈阳性。大多数（54%）HCoV阳性患者年龄在0至5岁之间。在这2年期间均检测到了HCoV，且通常在5月至10月达到高峰，这与雨季相符。基于刺突（S）基因序列比对的系统发育树表明出现了一个新的HCoV-229E进化枝。
结论
本研究中的数据为该地区近期流行的HCoV的流行情况提供了见解。
Zotero 插件