Hou Jian, Yang Yuqing, Huang Xiji, Song Yuanchao, Sun Huizhen, Wang Jianshu, Hou Fan, Liu Chuanyao, Chen Weihong, Yuan Jing
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, People's Republic of China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, People's Republic of China.
Environ Sci Pollut Res Int. 2016 Dec;23(23):23815-23824. doi: 10.1007/s11356-016-7491-6. Epub 2016 Sep 14.
Indoor air pollutants from environmental tobacco smoke and cooking fume can induce oxidative stress and inflammatory response, which generate oxidatively damaged DNA in human body. Among 2224 adults, levels of FENO and urinary 8-oxodG were measured using a nano coulomb nitric oxide analyzer and a high performance liquid chromatography system with electrochemical detector, respectively. Association between aging with higher FENO levels and urinary 8-oxodG levels were analyzed using multiple linear regression analysis. Nonsmoking women aged 64 years and over, with higher FENO (≥ 25 part per billion) and self-catering but without passive smoking had a higher risk of increased urinary 8-oxodG (△% of urinary 8-oxodG: 81.3 %, 95 % CI: 27.4-158.0 %) levels, particularly these elderly women with using liquefied petroleum gas for cooking, had a higher risk for increased urinary 8-oxodG levels (△% of urinary 8-oxodG: 100.2 %, 95 % CI: 95 % CI: 35.3-196.3 %), compared with those aged less than 64 years, with lower FENO (< 25 part per billion). Cooking activity aggravated aging-related the aging-induced in urinary 8-oxodG excretion among nonsmoking women aged 64 years and over but without passive smoking.
来自环境烟草烟雾和烹饪油烟的室内空气污染物可诱导氧化应激和炎症反应，进而在人体内产生氧化损伤的DNA。在2224名成年人中，分别使用纳米库仑一氧化氮分析仪和配备电化学检测器的高效液相色谱系统测量了呼出一氧化氮（FENO）水平和尿8-氧代脱氧鸟苷（8-oxodG）水平。采用多元线性回归分析来分析年龄增长与较高的FENO水平和尿8-oxodG水平之间的关联。64岁及以上的不吸烟女性，若FENO水平较高（≥25 ppb）且为自炊但无被动吸烟情况，则尿8-oxodG水平升高的风险更高（尿8-oxodG的变化百分比：81.3%，95%置信区间：27.4 - 158.0%），尤其是那些使用液化石油气烹饪的老年女性，与年龄小于64岁、FENO水平较低（<25 ppb）的女性相比，尿8-oxodG水平升高的风险更高（尿8-oxodG的变化百分比：100.2%，95%置信区间：35.3 - 196.3%）。烹饪活动加剧了64岁及以上无被动吸烟情况的不吸烟女性与衰老相关的尿8-oxodG排泄增加。
