Agnafors Sara, Svedin Carl Göran, Oreland Lars, Bladh Marie, Comasco Erika, Sydsjö Gunilla
Faculty of Health Sciences, Division of Child and Adolescent Psychiatry, IKE, Department of Clinical and Experimental Medicine, Linköping University, 581 85, Linköping, Sweden.
Department of Neuroscience, Uppsala University, 751 24, Uppsala, Sweden.
Child Psychiatry Hum Dev. 2017 Aug;48(4):584-596. doi: 10.1007/s10578-016-0684-x.
An increasing prevalence of mental health problems calls for more knowledge into factors associated with resilience. The present study used multiple statistical methodologies to examine a biopsychosocial model of risk and resilience on preadolescence behavior. Data from 889 children and mothers from a birth cohort were used. An adversity score was created by combining maternal symptoms of depression, psychosocial risk and children's experiences of life events. The proposed resilience factors investigated were candidate genetic polymorphisms, child temperament, social functioning, and maternal sense of coherence. The l/l genotype of the serotonin transporter linked polymorphic region was associated with lower internalizing scores, but not mainly related to the level of adversity. An easy temperament was associated with resilience for children exposed to high adversity. Social functioning was found to be promotive independent of the risk level. The results support a multiple-level model of resilience indicating effects, though small, of both biological and psychosocial factors.
心理健康问题患病率的上升需要我们更多地了解与心理韧性相关的因素。本研究采用多种统计方法来检验一个关于青春期前行为的风险和心理韧性的生物心理社会模型。研究使用了来自一个出生队列的889名儿童及其母亲的数据。通过综合母亲的抑郁症状、心理社会风险和儿童的生活事件经历来创建一个逆境分数。所研究的心理韧性因素包括候选基因多态性、儿童气质、社会功能和母亲的连贯感。血清素转运体连锁多态性区域的l/l基因型与较低的内化分数相关，但与逆境水平没有主要关联。对于面临高逆境的儿童，随和的气质与心理韧性相关。研究发现社会功能具有促进作用，且独立于风险水平。研究结果支持了一个心理韧性的多层次模型，表明生物因素和心理社会因素都有影响，尽管影响较小。
