Sohrab Golbon, Ebrahimof Samira, Sotoudeh Giti, Neyestani Tirang Reza, Angoorani Pooneh, Hedayati Mehdi, Siasi Fereidoun
a Department of Clinical Nutrition and dietetics, Faculty of Nutrition Sciences and Food Technology , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
b Cellular & Molecular Nutrition Department, Faculty of Nutrition Sciences and Food Technology , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Int J Food Sci Nutr. 2017 Mar;68(2):249-255. doi: 10.1080/09637486.2016.1229760. Epub 2016 Sep 16.
Increased free radicals production due to hyperglycemia produces oxidative stress in patients with diabetes. Pomegranate juice (PJ) has antioxidant properties. This study was conducted to determine the effects of PJ consumption in oxidative stress in type 2 diabetic patients. This study was a randomized clinical trial performed on 60, 40-65 years old diabetic patients. The patients were randomly allocated either to PJ consumption group or control. Patients in PJ group consumed 200 ml of PJ daily for six weeks. Sex distribution and the mean age were not different between two groups. After six weeks intervention, oxidized LDL and anti-oxidized LDL antibodies decreased and total serum antioxidant capacity and arylesterase activity of paraoxonase increased significantly in the PJ-treated group compared to the control group. Our data have shown that six weeks supplementation of PJ could have favorable effects on oxidative stress in patients with type 2 diabetes (T2D).
高血糖导致自由基生成增加，从而在糖尿病患者中产生氧化应激。石榴汁（PJ）具有抗氧化特性。本研究旨在确定饮用PJ对2型糖尿病患者氧化应激的影响。本研究是一项针对60名40 - 65岁糖尿病患者进行的随机临床试验。患者被随机分为饮用PJ组或对照组。PJ组患者每天饮用200毫升PJ，持续六周。两组之间的性别分布和平均年龄无差异。经过六周干预后，与对照组相比，PJ治疗组的氧化型低密度脂蛋白和抗氧化型低密度脂蛋白抗体降低，血清总抗氧化能力和对氧磷酶的芳基酯酶活性显著增加。我们的数据表明，六周补充PJ对2型糖尿病（T2D）患者的氧化应激可能有有益影响。
