Kohrman Abraham Q, Matus David Q
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-5215, USA.
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-5215, USA.
Trends Cell Biol. 2017 Jan;27(1):12-25. doi: 10.1016/j.tcb.2016.08.003. Epub 2016 Sep 12.
Cell invasion through the basement membrane (BM) occurs during normal embryonic development and is a fundamental feature of cancer metastasis. The underlying cellular and genetic machinery required for invasion has been difficult to identify, due to a lack of adequate in vivo models to accurately examine invasion in single cells at subcellular resolution. Recent evidence has documented a functional link between cell cycle arrest and invasive activity. While cancer progression is traditionally thought of as a disease of uncontrolled cell proliferation, cancer cell dissemination, a critical aspect of metastasis, may require a switch from a proliferative to an invasive state. In this work, we review evidence that BM invasion requires cell cycle arrest and discuss the implications of this concept with regard to limiting the lethality associated with cancer metastasis.
细胞通过基底膜（BM）的侵袭发生在正常胚胎发育过程中，是癌症转移的一个基本特征。由于缺乏足够的体内模型来以亚细胞分辨率准确检测单细胞的侵袭，侵袭所需的潜在细胞和遗传机制一直难以确定。最近的证据记录了细胞周期停滞与侵袭活性之间的功能联系。虽然传统上认为癌症进展是一种不受控制的细胞增殖疾病，但癌细胞扩散作为转移的一个关键方面，可能需要从增殖状态转变为侵袭状态。在这项工作中，我们回顾了基底膜侵袭需要细胞周期停滞的证据，并讨论了这一概念对于限制与癌症转移相关的致死率的意义。
