Dawson D E, Sekhar V, Pearson G, Vaickus L
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City.
Am J Otolaryngol. 1989 Jul-Aug;10(4):244-9. doi: 10.1016/0196-0709(89)90003-3.
The plasma of 15 normal volunteers, four patients with benign head and neck disease, and 12 patients with biopsy proven head and neck malignancies were evaluated using water-suppressed nuclear magnetic resonance (NMR) spectroscopy. While the mean full width at half height (HHLW) of the NMR spectra showed a significant difference between groups (P less than .05), the predictive value of a positive test was only 57% the sensitivity was only 33%, and individual values in all groups demonstrated considerable overlap. The mean HHLW of the control group was 38.5 Hz +/- 3.5 compared with 35.2 Hz +/- 4.7 for the cancer group and 35.0 Hz +/- 10 for the benign disease group. This method was not able to distinguish patients with malignancy from those with benign disease or controls. Its use as a specific screening method for head and neck malignancy cannot be recommended.
使用水抑制核磁共振（NMR）光谱对15名正常志愿者、4名患有良性头颈疾病的患者以及12名经活检证实患有头颈恶性肿瘤的患者的血浆进行了评估。虽然NMR光谱的平均半高全宽（HHLW）在各组之间存在显著差异（P小于0.05），但阳性检测的预测值仅为57%，灵敏度仅为33%，并且所有组中的个体值显示出相当大的重叠。对照组的平均HHLW为38.5 Hz±3.5，而癌症组为35.2 Hz±4.7，良性疾病组为35.0 Hz±10。该方法无法区分患有恶性肿瘤的患者与患有良性疾病的患者或对照组。不建议将其用作头颈恶性肿瘤的特异性筛查方法。
