利用血浆核磁共振波谱法检测肿瘤

Detection of tumours with nuclear magnetic resonance spectroscopy of plasma.

作者信息

Berger S, Pflüger K H, Etzel W A, Fischer J

机构信息

Fachbereich Chemie, Universität Marburg, F.R.G.

出版信息

Eur J Cancer Clin Oncol. 1989 Mar;25(3):535-43. doi: 10.1016/0277-5379(89)90267-8.

DOI:10.1016/0277-5379(89)90267-8

PMID:2703007

Abstract

A systematic investigation of cancer detection by water-suppressed nuclear magnetic resonance (NMR) of plasma is reported. With additional suppression of lactate, a statistically significant difference between the linewidths of the methylene group signal of patients with untreated cancer (average linewidth 26.9 +/- 3.9 Hz) and normal controls (average linewidth 31.1 +/- 4.9 Hz) has been found. However, overlap was found between these two groups. It is shown that recognition of malignancy could be improved by consideration of the different relations of the linewidths on the content of serum triglycerides and the observation of a shoulder at the high field side of the methylene signal. Preliminary investigations on lipid fractions separated by ultracentrifugation (UC) indicate a connection of the appearance of the high field shoulder and the HDL lipoprotein.

摘要

本文报道了一项通过血浆水抑制核磁共振（NMR）进行癌症检测的系统研究。在进一步抑制乳酸的情况下，发现未经治疗的癌症患者（平均线宽26.9±3.9Hz）和正常对照者（平均线宽31.1±4.9Hz）亚甲基信号的线宽之间存在统计学上的显著差异。然而，发现这两组之间存在重叠。结果表明，通过考虑线宽与血清甘油三酯含量的不同关系以及观察亚甲基信号高场侧的一个肩峰，可以提高对恶性肿瘤的识别。对超速离心（UC）分离的脂质组分的初步研究表明，高场肩峰的出现与高密度脂蛋白（HDL）有关。