Baddour L M, Gibbs R S, Mertz G, Cocchetto D M, Noble R C
Department of Medicine, University of Missouri-Columbia 65212.
Antimicrob Agents Chemother. 1989 Jun;33(6):801-4. doi: 10.1128/AAC.33.6.801.
Four hundred sixty-six female patients were enrolled in a randomized study that compared the clinical efficacies of single oral doses of cefuroxime axetil and amoxicillin with probenecid in the treatment of uncomplicated gonorrhea. Two hundred ninety-five patients had culture-positive gonococcal infections and completed the investigation. Cure rates for the patients treated with cefuroxime axetil and those treated with amoxicillin with probenecid were high (greater than 95%) for genitorectal infections. Pharyngeal infections, however, were not uniformly eradicated by either cefuroxime axetil (60%) or amoxicillin with probenecid (64%). Approximately 13% of each patient group suffered adverse events, which were gastrointestinal in the majority and were transient. Compared with amoxicillin plus probenecid, cefuroxime axetil in a single oral dose was an equally safe and effective drug for the treatment of uncomplicated gonorrhea in women caused by penicillin-susceptible strains.
466名女性患者参与了一项随机研究，该研究比较了单次口服头孢呋辛酯和阿莫西林加丙磺舒治疗单纯性淋病的临床疗效。295名患者淋病奈瑟菌感染培养呈阳性并完成了调查。对于泌尿生殖道感染，接受头孢呋辛酯治疗的患者和接受阿莫西林加丙磺舒治疗的患者治愈率很高（大于95%）。然而，头孢呋辛酯（60%）或阿莫西林加丙磺舒（64%）均不能完全根除咽部感染。每组患者中约13%出现不良事件，大多数为胃肠道不良事件且为短暂性。与阿莫西林加丙磺舒相比，单次口服头孢呋辛酯对于治疗由青霉素敏感菌株引起的女性单纯性淋病而言，是一种同样安全有效的药物。
