Reichman R C, Nolte F S, Wolinsky S M, Greisberger C A, Trupei M A, Nitzkin J
Sex Transm Dis. 1985 Oct-Dec;12(4):184-7. doi: 10.1097/00007435-198510000-00003.
One hundred eighty-four patients were enrolled in a randomized study that evaluated the efficacy and toxicity of a single dose of orally administered cefuroxine axetil in the treatment of men and women with uncomplicated gonorrhea. Sixty-two patients received cefuroxine axetil alone, 62 received cefuroxine axetil and probenecid, and 60 received amoxicillin plus probenecid. Cure rates in the three groups were 98%, 98%, 96%, respectively. Only 2% of patients who received cefuroxine axetil alone complained of nausea, as compared with 11% of those who received a regimen that contained probenecid (P less than .05). The results show that cefuroxime axetil is effective and nontoxic in the treatment of uncomplicated gonococcal infections in adults.
184名患者参与了一项随机研究，该研究评估了单剂量口服头孢呋辛酯在治疗无并发症淋病的男性和女性中的疗效和毒性。62名患者仅接受头孢呋辛酯治疗，62名患者接受头孢呋辛酯加丙磺舒治疗，60名患者接受阿莫西林加丙磺舒治疗。三组的治愈率分别为98%、98%、96%。仅接受头孢呋辛酯治疗的患者中只有2%抱怨恶心，而接受含丙磺舒治疗方案的患者中这一比例为11%（P小于0.05）。结果表明，头孢呋辛酯在治疗成人无并发症淋球菌感染方面有效且无毒。
