Wanas T M, Williams P E
Genitourin Med. 1986 Aug;62(4):221-3. doi: 10.1136/sti.62.4.221.
The efficacy and tolerance of single oral doses of cefuroxime axetil (1.5 g) were compared with oral ampicillin (3 g) for treating acute gonococcal urethritis in 110 men and 30 women. Each dose was given with 1 g probenecid. Of the 62 assessable patients who received ampicillin, two failed to respond to treatment. Of 67 assessable patients who received cefuroxime axetil, one failed to respond. Pencillinase producing strains of Neisseria gonorrhoeae were isolated from five patients; one received ampicillin and failed to respond, whereas the other four received cefuroxime axetil and three were cured. A single oral dose of 1.5 g cefuroxime axetil with 1 g probenecid seemed to be an effective treatment for acute gonococcal urethritis, especially for penicillin resistant strains.
将单次口服头孢呋辛酯（1.5克）与口服氨苄西林（3克）治疗110例男性和30例女性急性淋菌性尿道炎的疗效和耐受性进行了比较。每次给药时均加用丙磺舒1克。在接受氨苄西林治疗的62例可评估患者中，有2例治疗无效。在接受头孢呋辛酯治疗的67例可评估患者中，有1例治疗无效。从5例患者中分离出产青霉素酶的淋病奈瑟菌菌株；其中1例接受氨苄西林治疗无效，而其他4例接受头孢呋辛酯治疗，3例治愈。单次口服1.5克头孢呋辛酯加1克丙磺舒似乎是治疗急性淋菌性尿道炎的有效方法，尤其是对耐青霉素菌株。
