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用于近距离放射治疗计划的计算算法的基于胶片的验证——为MBDCA即将到来的挑战做好准备。

Film based verification of calculation algorithms used for brachytherapy planning-getting ready for upcoming challenges of MBDCA.

作者信息

Zwierzchowski Grzegorz, Bielęda Grzegorz, Skowronek Janusz, Mazur Magdalena

机构信息

Department of Electroradiology, Faculty of Health Sciences, Poznan University of Medical Sciences; Medical Physics Department, Greater Poland Cancer Centre.

Medical Physics Department, Greater Poland Cancer Centre.

出版信息

J Contemp Brachytherapy. 2016 Aug;8(4):326-35. doi: 10.5114/jcb.2016.61828. Epub 2016 Aug 16.

Abstract

PURPOSE

Well-known defect of TG-43 based algorithms used in brachytherapy is a lack of information about interaction cross-sections, which are determined not only by electron density but also by atomic number. TG-186 recommendations with using of MBDCA (model-based dose calculation algorithm), accurate tissues segmentation, and the structure's elemental composition continue to create difficulties in brachytherapy dosimetry. For the clinical use of new algorithms, it is necessary to introduce reliable and repeatable methods of treatment planning systems (TPS) verification. The aim of this study is the verification of calculation algorithm used in TPS for shielded vaginal applicators as well as developing verification procedures for current and further use, based on the film dosimetry method.

MATERIAL AND METHODS

Calibration data was collected by separately irradiating 14 sheets of Gafchromic(®) EBT films with the doses from 0.25 Gy to 8.0 Gy using HDR (192)Ir source. Standard vaginal cylinders of three diameters were used in the water phantom. Measurements were performed without any shields and with three shields combination. Gamma analyses were performed using the VeriSoft(®) package.

RESULTS

Calibration curve was determined as third-degree polynomial type. For all used diameters of unshielded cylinder and for all shields combinations, Gamma analysis were performed and showed that over 90% of analyzed points meets Gamma criteria (3%, 3 mm).

CONCLUSIONS

Gamma analysis showed good agreement between dose distributions calculated using TPS and measured by Gafchromic films, thus showing the viability of using film dosimetry in brachytherapy.

摘要

目的

近距离放射治疗中使用的基于TG - 43的算法的一个众所周知的缺陷是缺乏关于相互作用截面的信息,相互作用截面不仅由电子密度决定,还由原子序数决定。TG - 186关于使用MBDCA(基于模型的剂量计算算法)、精确的组织分割和结构的元素组成的建议,在近距离放射治疗剂量测定中仍然存在困难。对于新算法的临床应用,有必要引入可靠且可重复的治疗计划系统(TPS)验证方法。本研究的目的是验证TPS中用于屏蔽阴道施源器的计算算法,并基于胶片剂量测定法开发当前及进一步使用的验证程序。

材料与方法

使用高剂量率(HDR)(192)铱源,分别用0.25 Gy至8.0 Gy的剂量照射14张Gafchromic(®)EBT胶片,收集校准数据。在水模体中使用三种直径的标准阴道圆柱体。测量在无任何屏蔽以及三种屏蔽组合的情况下进行。使用VeriSoft(®)软件包进行伽马分析。

结果

校准曲线确定为三次多项式类型。对于所有使用的无屏蔽圆柱体直径以及所有屏蔽组合,均进行了伽马分析,结果表明超过90%的分析点符合伽马标准(3%,3毫米)。

结论

伽马分析表明,TPS计算的剂量分布与Gafchromic胶片测量的剂量分布之间具有良好的一致性,从而表明在近距离放射治疗中使用胶片剂量测定法的可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3987/5018527/5be70402b59f/JCB-8-28183-g001.jpg

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