Jean-Joseph Jerome, Balagiannis Nikolaus, Scheppach Markus W, Temizel Selin, Ebigbo Alanna, Messmann Helmut, Janzen Tilman, Stüben Georg
Medical Physics Department, Augsburg University Hospital, Augsburg, Germany.
Radiotherapy Department, Augsburg University Hospital, Augsburg, Germany.
J Contemp Brachytherapy. 2025 Feb;17(1):33-42. doi: 10.5114/jcb.2025.147780. Epub 2025 Feb 19.
In this study, a novel auxetic applicator equipped with four-channel catheters for esophageal brachytherapy was presented.
The applicator, made of a new biocompatible material, has an auxetic helical structure with four channels. Details of applicator modeling, construction, commissioning, and insertion were provided. Initial trial conducted on a porcine model was outlined.
Simulations and dose calculations closely matched experimental measurements, validating the modeling approach. This applicator achieved highly asymmetric dose distributions. Its unique auxetic helical design allowed smooth insertion, while mitigating sequential inter-fraction hot spot formation.
implementation of the applicator demonstrated feasibility, resulting in consistent and reproducible dose distributions. Initial outcomes showed promise for the applicator's efficacy and versatility in intra-luminal or intra-cavitary applications.
在本研究中,提出了一种配备四通道导管用于食管近距离放射治疗的新型负泊松比敷贴器。
该敷贴器由一种新型生物相容性材料制成,具有带四个通道的负泊松比螺旋结构。提供了敷贴器建模、构造、调试和插入的详细信息。概述了在猪模型上进行的初步试验。
模拟和剂量计算与实验测量结果密切匹配,验证了建模方法。该敷贴器实现了高度不对称的剂量分布。其独特的负泊松比螺旋设计允许顺利插入,同时减轻了分次间热点的形成。
敷贴器的应用证明了其可行性,可产生一致且可重复的剂量分布。初步结果显示该敷贴器在腔内或腔内应用中的疗效和多功能性具有前景。