Sawka M N, Young A J, Dennis R C, Gonzalez R R, Pandolf K B, Valeri C R
U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007.
Aviat Space Environ Med. 1989 Jul;60(7):634-8.
Several investigators have suggested that prolonged exercise and hypohydration alter the intravascular mass of immunoglobulins. Those studies, however, have methodological concerns which make generalizations from their data very tenuous. This study examined the effects of prolonged moderate intensity exercise in the heat and hypohydration on changes in the intravascular mass of immunoglobulins. Five heat-acclimated males attempted two Heat Stress Tests (HSTs). One HST was completed when subjects were euhydrated and the other HST when subjects were hypohydrated (-5% from base line body weight). The HSTs consisted of 30 min of rest in a 20 degrees C antechamber, followed by a 120-min exposure (2 repeats of 15 min rest and 45 min walking) in a hot (35 degrees C, 45% rh) environment. The following observations were made concerning immunoglobulin responses to hypohydration and exercise-heat stress: a) the changes in concentrations (mg.dl-1) of the measured immunoglobulins were often a reflection of changes in the plasma volume; b) hypohydration increased the intravascular mass (g) of the complement enzyme C3 during resting conditions, but did not alter the intravascular mass of IgG, IgA, and IgM, and c) prolonged treadmill exercise in the heat, when either euhydrated or hypohydrated, did not alter the intravascular mass of IgG, IgA, IgM, and C3. These data indicate that the intravascular mass of immunoglobulins does not change during prolonged moderate intensity exercise in the heat, and that hypohydration results in a translocation of C3 to the intravascular space. In addition, these data indicate that immunoglobulins do not provide a stress index for hypohydration.
几位研究者提出，长时间运动和水分摄入不足会改变血管内免疫球蛋白的量。然而，这些研究存在方法学方面的问题，使得从其数据得出的普遍性结论非常不可靠。本研究考察了在炎热环境下长时间中等强度运动以及水分摄入不足对血管内免疫球蛋白量变化的影响。五名经过热适应的男性尝试了两次热应激测试（HST）。一次HST是在受试者水分正常时完成的，另一次HST是在受试者水分摄入不足时（相对于基线体重减少5%）完成的。热应激测试包括在20摄氏度的前厅休息30分钟，随后在炎热（35摄氏度，相对湿度45%）环境中暴露120分钟（15分钟休息和45分钟步行重复两次）。关于免疫球蛋白对水分摄入不足以及运动-热应激的反应，有以下观察结果：a）所测免疫球蛋白浓度（mg·dl-1）的变化往往反映了血浆量的变化；b）水分摄入不足在静息状态下增加了补体酶C3的血管内量（g），但未改变IgG、IgA和IgM的血管内量，并且c）在炎热环境下进行长时间跑步机运动时，无论水分正常还是水分摄入不足，均未改变IgG、IgA、IgM和C3的血管内量。这些数据表明，在炎热环境下长时间中等强度运动期间，免疫球蛋白的血管内量不会改变，且水分摄入不足会导致C3转移至血管内空间。此外，这些数据表明免疫球蛋白不能作为水分摄入不足的应激指标。
