FTO基因分型与体重减轻：对来自八项随机对照试验的9563名个体参与者数据的系统评价和荟萃分析。
FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.
作者信息
Livingstone Katherine M, Celis-Morales Carlos, Papandonatos George D, Erar Bahar, Florez Jose C, Jablonski Kathleen A, Razquin Cristina, Marti Amelia, Heianza Yoriko, Huang Tao, Sacks Frank M, Svendstrup Mathilde, Sui Xuemei, Church Timothy S, Jääskeläinen Tiina, Lindström Jaana, Tuomilehto Jaakko, Uusitupa Matti, Rankinen Tuomo, Saris Wim H M, Hansen Torben, Pedersen Oluf, Astrup Arne, Sørensen Thorkild I A, Qi Lu, Bray George A, Martinez-Gonzalez Miguel A, Martinez J Alfredo, Franks Paul W, McCaffery Jeanne M, Lara Jose, Mathers John C
机构信息
Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE4 5PL, UK Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Victoria, Australia.
Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE4 5PL, UK BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK.
出版信息
BMJ. 2016 Sep 20;354:i4707. doi: 10.1136/bmj.i4707.
OBJECTIVE
To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.
DESIGN
Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.
DATA SOURCES
Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.
ELIGIBILITY CRITERIA FOR STUDY SELECTION
Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity.
RESULTS
We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category.
CONCLUSIONS
We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42015015969.
目的
在随机对照试验中，评估FTO基因分型对饮食、体育活动或药物干预后体重减轻的影响。
设计
对随机对照试验中个体参与者数据进行系统评价和随机效应荟萃分析。
数据来源
自数据库建立至2015年11月的Ovid Medline、Scopus、Embase和Cochrane数据库。
研究选择的纳入标准
超重或肥胖成年人的随机对照试验，报告饮食、体育活动或药物干预后，按FTO基因分型（rs9939609或其替代指标）得出的体重指数、体重或腰围的降低情况。对本评价纳入的所有研究的个体参与者数据拟合基因与治疗相互作用模型，使用等位基因剂量编码遗传效应和一组共同的协变量。采用随机效应模型合并研究水平的相互作用。使用Meta回归和亚组分析评估研究异质性的来源。
结果
我们确定了8项符合条件的随机对照试验用于系统评价和荟萃分析（n=9563）。总体而言，FTO基因分型之间，体重减轻干预后体重指数、体重和腰围的差异变化无显著差异。敏感性分析表明，FTO基因分型导致的体重指数、体重和腰围的差异变化在干预类型、干预时长、种族、样本量、性别以及基线体重指数和年龄类别方面无差异。
结论
我们观察到，携带FTO次要等位基因与体重减轻干预后肥胖程度的差异变化无关。这些发现表明，携带次要等位基因的个体对饮食、体育活动或药物减肥干预的反应同样良好，因此，与FTO次要等位基因相关的肥胖遗传易感性可通过此类干预至少部分得到抵消。
系统评价注册
PROSPERO CRD42015015969。
Zotero 插件