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本文引用的文献

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Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility.人类自然杀伤细胞库的多样性反映了免疫经历，并与病毒易感性相关。
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孕期单核细胞和浆细胞样树突状细胞对甲型流感病毒感染的促炎反应增强。

Increased Proinflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy.

作者信息

Le Gars Mathieu, Kay Alexander W, Bayless Nicholas L, Aziz Natali, Dekker Cornelia L, Swan Gary E, Davis Mark M, Blish Catherine A

机构信息

Department of Medicine.

Stanford Immunology.

出版信息

J Infect Dis. 2016 Dec 1;214(11):1666-1671. doi: 10.1093/infdis/jiw448. Epub 2016 Sep 21.

DOI:10.1093/infdis/jiw448
PMID:27655870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5144734/
Abstract

Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to influenza A virus infection in 21 pregnant and 21 nonpregnant women. In pregnant women, monocytes and pDCs exhibit an exaggerated proinflammatory immune response to 2 strains of influenza A virus, compared with nonpregnant women, characterized by increased expression of major histocompatibility complex class II (approximately 2.0-fold), CD69 (approximately 2.2-fold), interferon γ-induced protein 10 (approximately 2.0-fold), and macrophage inflammatory protein 1β (approximately 1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following influenza A virus infection.

摘要

孕期免疫的改变可能导致孕期甲型流感病毒感染相关发病率增加。我们对21名孕妇和21名非孕妇的单核细胞和浆细胞样树突状细胞（pDC）对甲型流感病毒感染的免疫反应进行了表征。与非孕妇相比，孕妇的单核细胞和pDC对两株甲型流感病毒表现出过度的促炎免疫反应，其特征是主要组织相容性复合体II类（约2.0倍）、CD69（约2.2倍）、干扰素γ诱导蛋白10（约2.0倍）和巨噬细胞炎性蛋白1β（约1.5倍）的表达增加。孕期这种增强的先天性炎症反应可能导致甲型流感病毒感染后的肺部炎症。