Mozurkewich Ellen L, Greenwood Matthew, Clinton Chelsea, Berman Deborah, Romero Vivian, Djuric Zora, Qualls Clifford, Gronert Karsten
Obstetrics and Gynecology, University of New MexicoAlbuquerque, NM, USA; Obstetrics and Gynecology, University of MichiganAnn Arbor, MI, USA.
Vision Science Program, Infectious Diseases and Immunity Program, School of Optometry, University of California at Berkeley Berkeley, CA, USA.
Front Pharmacol. 2016 Sep 7;7:274. doi: 10.3389/fphar.2016.00274. eCollection 2016.
The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are precursors to immune regulatory and specialized pro-resolving mediators (SPM) of inflammation termed resolvins, maresins, and protectins. Evidence for lipid mediator formation in vivo can be gained through evaluation of their 5-lipoxygenase (LOX) and 15-LOX metabolic pathway precursors and downstream metabolites. We performed a secondary blood sample analysis from 60 participants in the Mothers, Omega-3, and Mental Health study to determine whether SPM and SPM precursors are augmented by dietary EPA- and DHA-rich fish oil supplementation compared to soy oil placebo. We also aimed to study whether SPM and their precursors differ in early and late pregnancy or between maternal and umbilical cord blood. We found that compared to placebo supplementation, EPA- and DHA-rich fish oil supplementation increased SPM precursor 17-hydroxy docosahexaenoic acid (17-HDHA) concentrations in maternal and umbilical cord blood (P = 0.02). We found that the D-series resolvin pathway marker 17-HDHA increased significantly between enrollment and late pregnancy (P = 0.049). Levels of both 14-HDHA, a maresin pathway marker, and 17-HDHA were significantly greater in umbilical cord blood than in maternal blood (P < 0.001, both).
ω-3脂肪酸二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）是免疫调节因子和炎症特异性促消退介质（SPM）的前体，这些介质包括消退素、maresin和保护素。通过评估其5-脂氧合酶（LOX）和15-LOX代谢途径的前体及下游代谢产物，可以获得体内脂质介质形成的证据。我们对“母亲、ω-3与心理健康”研究中的60名参与者进行了二次血液样本分析，以确定与大豆油安慰剂相比，富含EPA和DHA的膳食鱼油补充剂是否会增加SPM及其前体。我们还旨在研究SPM及其前体在妊娠早期和晚期之间，或母体血与脐带血之间是否存在差异。我们发现，与补充安慰剂相比，富含EPA和DHA的鱼油补充剂增加了母体血和脐带血中SPM前体17-羟基二十二碳六烯酸（17-HDHA）的浓度（P = 0.02）。我们发现，D系列消退素途径标志物17-HDHA在入组时和妊娠晚期之间显著增加（P = 0.049）。脐带血中maresin途径标志物14-HDHA和17-HDHA的水平均显著高于母体血（两者P均< 0.001）。
