Jung Seungyoun, Smith-Warner Stephanie A, Willett Walter C, Wang Molin, Wu Tianying, Jensen Majken, Hankinson Susan E, Eliassen A Heather
Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Nutrients. 2016 Sep 21;8(9):587. doi: 10.3390/nu8090587.
Healthy diets may lower oxidative stress and risk of chronic diseases. However, no previous studies examined associations between diet and fluorescent oxidation products (FlOP), a global marker of oxidative stress. We evaluated associations between healthy eating patterns (Alternative Healthy Eating Index (AHEI), Dietary Approach to Stop Hypertension (DASH), and Alternate Mediterranean Diet (aMED)) and FlOP, measured at three excitation/emission wavelengths (FlOP_360, FlOP_320, FlOP_400) from 2021 blood samples collected from 1688 women within the Nurses' Health Study. AHEI, DASH, and aMED scores were significantly positively associated with FlOP_360 and FlOP_320 concentrations (-trend ≤ 0.04), but not associated with FlOP_400. Among specific food groups that contribute to these diet scores, significantly positive associations were observed with legumes and vegetables for FlOP_360, vegetables and fruits for FlOP_320, and legumes and alcohol for FlOP_400. Inverse associations were observed with nuts, sweets or desserts, and olive oil for FlOP_360, nuts for FlOP_320 and sweets or desserts for FlOP_400 (all -trend ≤ 0.05). However, FlOP variation due to diet was small compared to overall FlOP variation. In conclusion, AHEI, DASH, and aMED scores were unexpectedly positively, but weakly, associated with FlOP_360 and FlOP_320. However, these findings should be interpreted cautiously as the determinants of FlOP concentrations are not fully understood.
健康饮食可能会降低氧化应激和慢性病风险。然而,以往尚无研究探讨饮食与荧光氧化产物(FlOP,氧化应激的一种整体标志物)之间的关联。我们评估了健康饮食模式(替代健康饮食指数(AHEI)、终止高血压膳食方法(DASH)和替代地中海饮食(aMED))与FlOP之间的关联,FlOP是通过对从护士健康研究中的1688名女性2021年采集的血液样本在三个激发/发射波长(FlOP_360、FlOP_320、FlOP_400)下进行测量得到的。AHEI、DASH和aMED评分与FlOP_360和FlOP_320浓度显著正相关(-趋势≤0.04),但与FlOP_400无关。在对这些饮食评分有贡献的特定食物组中,观察到FlOP_360与豆类和蔬菜、FlOP_320与蔬菜和水果、FlOP_400与豆类和酒精之间存在显著正相关。观察到FlOP_360与坚果、糖果或甜点以及橄榄油、FlOP_320与坚果、FlOP_400与糖果或甜点之间呈负相关(所有-趋势≤0.05)。然而,与整体FlOP变化相比,饮食导致的FlOP变化较小。总之,AHEI、DASH和aMED评分出人意料地与FlOP_360和FlOP_320呈正相关,但相关性较弱。然而,由于FlOP浓度的决定因素尚未完全明了,这些发现应谨慎解读。