Department of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
Department of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Nutrients. 2021 Apr 17;13(4):1337. doi: 10.3390/nu13041337.
Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points ( ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 ( = 0.03), 15 ( = 0.057) and 30 ( = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures.
暴露于污染物中的患者更有可能患过敏性鼻炎，并可能受益于抗氧化治疗。我们的研究旨在确定患有草诱发过敏性鼻炎的患者是否可以从西兰花芽提取物（BSE）补充中受益。共有 47 名患者被确诊为草诱发过敏性鼻炎，并随机分为四组之一：第 1 组（鼻用类固醇喷雾+BSE）、第 2 组（鼻用类固醇喷雾+安慰剂片）、第 3 组（盐水鼻腔喷雾+BSE）和第 4 组（盐水鼻腔喷雾+安慰剂片）。在干预前和干预后收集的样本中分析了峰值鼻吸气流量（PNIF）、总鼻部症状评分（TNSS）和鼻粘液细胞因子水平。与安慰剂相比，在鼻挑战后 5、15、60 和 240 分钟的各个时间点，第 1 组和第 2 组的 PNIF 在干预前后均显著改善（≤0.05），而 TNSS 仅在 5 分钟（=0.03）、15 分钟（=0.057）和 30 分钟（=0.05）时具有统计学意义。干预前后各种细胞因子标志物无统计学差异。鼻用皮质类固醇与 BSE 联合使用可显著改善客观指标。
