Salci E Sinem Ozdemir, Demirbilek Serpil Kahya, Gunes Nazmiye, Goncagul Gulsen, Uzabacı Ender, Carli Tayfun, Seyrek-Intas Kamil
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2018 Feb;46(1):22-28. doi: 10.15653/TPG-170136. Epub 2018 Feb 21.
This study aimed to compare different induction of partu -rition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs.
A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses. Colostrum and blood samples were collected from the lambs at 0, 12, 24, 36 and 48 hours for the IgG analysis. The prolactin, oxytocin and IgG levels were measured by ELISA.
A significant difference was found in prolactin levels in all groups and in the colostral IgG level in group IV with respect to the sampling time. Additionally, a significant difference in prolactin level was found at 24 hours postpartum between group IV and groups I and III. A significant difference in the colostral IgG level was determined at 24 hours after parturition between group III and the other groups and at 48 hours after parturition between groups II and III. A positive and significant correlation between the colostral and serum IgG levels of the lambs was found at 24 hours in groups I and II.
Although varying individual results were found within the groups, the endocrinological and immunological results did not suggest any superiority among the IP methods. Considering the presented study results, a single dose of aglepristone may be used alone or in combination with dexamethasone for I P.
本研究旨在比较不同引产方法对母羊和羔羊内分泌及免疫参数的影响。
共研究24只母羊及其对应的24只羔羊。在第138天对每组6只母羊进行引产：第一组（对照组）、第二组（地塞米松组）、第三组（阿孕瑞司酮组）和第四组（阿孕瑞司酮+地塞米松组）。从引产至产后2天，每隔12小时采集母羊血液样本进行催乳素和催产素分析。在0、12、24、36和48小时采集羔羊的初乳和血液样本进行IgG分析。通过酶联免疫吸附测定法（ELISA）测量催乳素、催产素和IgG水平。
所有组的催乳素水平以及第四组的初乳IgG水平在采样时间方面存在显著差异。此外，产后24小时时，第四组与第一组和第三组之间的催乳素水平存在显著差异。分娩后24小时时，第三组与其他组之间的初乳IgG水平存在显著差异，分娩后48小时时，第二组与第三组之间的初乳IgG水平存在显著差异。在第一组和第二组中，发现羔羊在24小时时初乳和血清IgG水平之间存在正相关且显著相关。
尽管各组内个体结果有所不同，但内分泌和免疫结果并未表明引产方法之间存在任何优势。考虑到本研究结果，单剂量阿孕瑞司酮可单独使用或与地塞米松联合用于引产。
