Shepard J S, Pettengill O S, Wurster-Hill D H, Sorenson G D
J Natl Cancer Inst. 1978 Jul;61(1):255-8. doi: 10.1093/jnci/61.1.255.
The chromosomes of uncultured cells of the near-diploid mouse plasmacytoma MOPC-31C were studied. The modal number of chromosomes was 44. The tumor lacked two marker chromosomes, reciprocal translocation [rcp t(12; 15)], that in previous studies were found to be common to 3 other uncultured myelomas and 1 cultured mouse myeloma. Through the formation of two markers, rcp t(6; 15), unique to this tumor, however, the tumor shared with other tumors and their specific markers a common breakpoint in chromosome "15 at band D3/E. This breakpoint has been found in all mouse plasmacytomas examined with banding thus far and is considered of possible importance in the development of this tumor.
对近二倍体小鼠浆细胞瘤MOPC - 31C的未培养细胞的染色体进行了研究。染色体众数为44。该肿瘤缺少两条标记染色体，即相互易位[rcp t(12; 15)]，在先前的研究中发现这两条染色体在另外3种未培养的骨髓瘤和1种培养的小鼠骨髓瘤中很常见。然而，通过形成该肿瘤特有的两条标记染色体rcp t(6; 15)，该肿瘤与其他肿瘤及其特定标记染色体在“15号染色体的D3/E带处有一个共同的断点。到目前为止，在用显带技术检查的所有小鼠浆细胞瘤中都发现了这个断点，并且认为它在该肿瘤的发生发展中可能具有重要意义。
