Yoshida M C, Moriwaki K, Migita S
J Natl Cancer Inst. 1978 Jan;60(1):235-8. doi: 10.1093/jnci/60.1.235.
Q-banding studies in two independent hyperdiploid mouse plasmacytomas, 63-1 and the NP-38-ABCD subline of MSPC-1, revealed that deletion of a No. 15 chromosome was common. The deletion of No. 15 appeared to result from a translocation between No. 12 and 15 in the NP-38-ABCD, as in most plasmacytomas. In 63-1, however, No. 10 was probably a recipient chromosome of the missing segment from the deleted No. 15, and both chromosomes No. 12 remained intact. These karyotypic features suggest that the deleted No. 15 is a tumor-specific marker chromosome in mouse plasmacytoma and that an abnormality of No. 12 is not essential for development of the tumor. The constitution of chromosomes in the two plasmacytomas remained remarkably stable in their homogeneous modal population.
对两个独立的超二倍体小鼠浆细胞瘤63 - 1和MSPC - 1的NP - 38 - ABCD亚系进行的Q带研究表明，15号染色体缺失很常见。与大多数浆细胞瘤一样，NP - 38 - ABCD中15号染色体的缺失似乎是由12号和15号染色体之间的易位导致的。然而，在63 - 1中，10号染色体可能是缺失的15号染色体片段的接受染色体，且两条12号染色体均保持完整。这些核型特征表明，缺失的15号染色体是小鼠浆细胞瘤中的肿瘤特异性标记染色体，并且12号染色体的异常对于肿瘤的发生并非必不可少。在这两个浆细胞瘤的同质众数群体中，染色体组成保持着显著的稳定性。
