Bear Joseph C, Patrick P Stephen, Casson Alfred, Southern Paul, Lin Fang-Yu, Powell Michael J, Pankhurst Quentin A, Kalber Tammy, Lythgoe Mark, Parkin Ivan P, Mayes Andrew G
Materials Chemistry Centre, Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Centre for Advanced Biomedical Imaging (CABI), Department of Medicine and Institute of Child Health, University College London, London WC1E 6DD, UK.
Sci Rep. 2016 Sep 27;6:34271. doi: 10.1038/srep34271.
Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it's drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane- superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.
由于任何药物递送载体在释放其药物载荷之前都必须经历恶劣的环境，因此将药物递送至胃肠道（GI）极具挑战性。有效的靶向药物递送系统通常依赖外部刺激来实现释放，因此了解胶囊的确切位置以及何时施加外部刺激至关重要。我们展示了一种用于胃肠道的药物递送系统，该系统基于用模型二十烷 - 超顺磁性氧化铁纳米颗粒复合涂层包覆标准明胶药物胶囊，该涂层通过磁热疗作为按需释放机制来加热和熔化涂层。我们还表明，通过快速X射线计算机断层扫描（CT）和磁共振成像（MRI）可以很容易地检测到这些胶囊，这对于将这样的系统推进到临床应用至关重要。这也为在药物释放后对药物载荷的分散情况进行成像提供了机会。这些成像技术还影响了胶囊的内容物、设计以及所递送的剂型。能够轻松改变设计证明了该系统的多功能性，这是现代个性化医疗的一个至关重要的优势。
