Patrick P Stephen, Bogart Lara K, Macdonald Thomas J, Southern Paul, Powell Michael J, Zaw-Thin May, Voelcker Nicolas H, Parkin Ivan P, Pankhurst Quentin A, Lythgoe Mark F, Kalber Tammy L, Bear Joseph C
Centre for Advanced Biomedical Imaging (CABI) , Department of Medicine , University College London , London WC1E 6DD , UK . Email:
UCL Healthcare Biomagnetics Laboratory , 21 Albemarle Street , London , W1S 4BS , UK.
Chem Sci. 2019 Jan 9;10(9):2592-2597. doi: 10.1039/c8sc04895a. eCollection 2019 Mar 7.
We introduce the concept of surface radio-mineralisation (SRM) to describe the chelate-free radiolabelling of iron-oxide and ferrite nanoparticles. We demonstrate the effectiveness of SRM with both In and Zr for bare, polymer-matrix multicore, and surface-functionalised magnetite/maghemite nanoparticles; and for bare YFeO nanoparticles. By analogy with geological mineralisation (the hydrothermal deposition of metals as minerals in ore bodies or lodes) we demonstrate that the heat-induced and aqueous SRM process deposits radiometal-oxides onto the nanoparticle or core surfaces, passing through the matrix or coating if present, without changing the size, structure, or magnetic properties of the nanoparticle or core. We show in a mouse model followed over 7 days that the SRM is sufficient to allow quantitative, non-invasive, prolonged, whole-body localisation of injected nanoparticles with nuclear imaging.
我们引入表面放射性矿化（SRM）的概念来描述氧化铁和铁氧体纳米颗粒的无螯合放射性标记。我们证明了SRM对铟和锆在裸露的、聚合物基质多核以及表面功能化的磁铁矿/磁赤铁矿纳米颗粒；以及裸露的钇铁氧体纳米颗粒上的有效性。通过类比地质矿化（金属以矿物形式在矿体或矿脉中的热液沉积），我们证明热诱导的水性SRM过程将放射性金属氧化物沉积在纳米颗粒或核表面，如有基质或涂层则穿过它们，而不会改变纳米颗粒或核的尺寸、结构或磁性。我们在一个持续7天的小鼠模型中表明，SRM足以通过核成像对注射的纳米颗粒进行定量、非侵入性、长时间的全身定位。
