用于筛查地中海人群骨密度的风险评估工具。
Risk assessment instruments for screening bone mineral density in a Mediterranean population.
作者信息
Christodoulou Sotirios, Drosos Georgios I, Ververidis Athanasios, Galanos Antonios, Anastassopoulos George, Kazakos Konstantinos
机构信息
Sotirios Christodoulou, Georgios I Drosos, Athanasios Ververidis, Konstantinos Kazakos, Department of Orthopaedic Surgery, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
出版信息
World J Orthop. 2016 Sep 18;7(9):577-83. doi: 10.5312/wjo.v7.i9.577.
AIM
To evaluate the power of six osteoporosis-screening instruments in women in a Mediterranean country.
METHODS
Data concerning several osteoporosis risk factors were prospectively collected from 1000 postmenopausal women aged 42-87 years who underwent dual-energy X-ray absorptiometry (DEXA) screening. Six osteoporosis risk factor screening tools were applied to this sample to evaluate their performance and choose the most appropriate tool for the study population.
RESULTS
The most important screening tool for osteoporosis status was the Simple Calculated Osteoporosis Risk Estimation, which had an area under the curve (AUC) of 0.678, a sensitivity of 72%, and a specificity of 72%, with a cut-off point of 20.75. The most important screening tool for osteoporosis risk was the Osteoporosis Self-assessment Tool, which had an AUC of 0.643, a sensitivity of 77%, and a specificity of 46%, with a cut-off point of -2.9.
CONCLUSION
Some commonly used clinical risk instruments demonstrate high sensitivity for distinguishing individuals with DEXA-ascertained osteoporosis or reduced bone mineral density.
目的
评估六种骨质疏松症筛查工具在地中海国家女性中的效能。
方法
前瞻性收集了1000名年龄在42 - 87岁接受双能X线吸收法（DEXA）筛查的绝经后女性的多种骨质疏松症风险因素数据。将六种骨质疏松症风险因素筛查工具应用于该样本，以评估其性能，并为研究人群选择最合适的工具。
结果
用于评估骨质疏松症状态的最重要筛查工具是简易计算骨质疏松症风险评估法，其曲线下面积（AUC）为0.678，灵敏度为72%，特异性为72%，截断点为20.75。用于评估骨质疏松症风险的最重要筛查工具是骨质疏松症自我评估工具，其AUC为0.643，灵敏度为77%，特异性为46%，截断点为 - 2.9。
结论
一些常用的临床风险评估工具在区分经DEXA确定患有骨质疏松症或骨密度降低的个体时显示出高灵敏度。
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