State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, China.
Org Lett. 2016 Oct 7;18(19):5146-5149. doi: 10.1021/acs.orglett.6b02572. Epub 2016 Sep 27.
Two pairs of oligomeric coumarin enantiomers, spirotriscoumarin A [(+)-1 and (-)-1] and spirotriscoumarin B [(+)-2 and (-)-2], with a spirodienone-sesquiterpene fused skeleton were isolated from Toddalia asiatica. Their structures were unambiguously established using spectroscopic data, X-ray diffraction analysis, and the electronic circular dichroism (ECD) method. The racemic mixtures (±)-1 and (±)-2 exhibit 3-to-6-fold stronger antiviral activity against influenza virus A (H3N2) (IC: 3.13 and 2.87 μM, respectively) than their corresponding optically pure enantiomers.
从苦茄中分离得到两对具有螺二氢呋喃-倍半萜骨架的寡聚香豆素对映体，螺三香豆素 A [(+)-1 和 (-)-1]和螺三香豆素 B [(+)-2 和 (-)-2]。利用光谱数据、X 射线衍射分析和电子圆二色性 (ECD) 方法，明确了它们的结构。外消旋混合物 (±)-1 和 (±)-2 对流感病毒 A (H3N2) 的抗病毒活性比其相应的光学纯对映体强 3 至 6 倍 (IC：分别为 3.13 和 2.87 μM)。
