Wong Ang-Peng, Niedzwiecki Aleksandra, Rath Matthias
Department of Graduate Studies, Research and Commercialization, Cyberjaya University College of Medical Sciences Selangor, Malaysia.
Dr. Rath Research Institute Santa Clara, CA 95050, USA.
Am J Cardiovasc Dis. 2016 Sep 15;6(3):81-92. eCollection 2016.
Heart failure is a multifactorial disease with poor prognosis. There are many hypotheses regarding the cause of heart failure. Leading among them are the hemodynamic and the neuro-hormonal hypotheses. Although the energy depletion hypothesis has been fairly recent, there is evidence suggesting that declining bioenergy plays a major role in heart failure. This review explored the myocardial energy depletion hypothesis from the role of micronutrients in correcting and alleviating symptoms of heart failure. Even though focus was on key nutrients such as coenzyme Q10, thiamine, riboflavin, L-carnitine, and taurine, emphasis was on the combined effect of multiple micronutrients as a whole. Search from databases from 2000 to 2015 produced four clinical studies using multiple micronutrients on heart failure. Evidence from the studies show that using high doses of multiple micronutrients may have positive effects on heart failure and simultaneously support the myocardial energy depletion hypothesis.
心力衰竭是一种预后不良的多因素疾病。关于心力衰竭的病因有许多假说。其中主要的是血流动力学假说和神经激素假说。尽管能量耗竭假说提出的时间相对较近，但有证据表明生物能量下降在心力衰竭中起主要作用。本综述从微量营养素在纠正和缓解心力衰竭症状中的作用方面探讨了心肌能量耗竭假说。尽管重点关注辅酶Q10、硫胺素、核黄素、左旋肉碱和牛磺酸等关键营养素，但强调的是多种微量营养素作为一个整体的联合作用。对2000年至2015年数据库的检索产生了四项关于使用多种微量营养素治疗心力衰竭的临床研究。这些研究的证据表明，使用高剂量的多种微量营养素可能对心力衰竭有积极作用，同时支持心肌能量耗竭假说。
