Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC), Thuwal, 23955-6900, Saudi Arabia.
Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13602-13605. doi: 10.1002/anie.201606197. Epub 2016 Sep 29.
A dual catalytic iron/lipase system has been developed and applied in the dynamic kinetic resolution of benzylic and aliphatic secondary alcohols. A detailed study of the Knölker-type iron complexes demonstrated the hydrogen autotransfer of alcohols to proceed under mild reaction conditions and allowed the combination with the enzymatic resolution. Different racemic alcohols were efficiently converted to chiral acetates in good yields and with excellent enantioselectivities.
已开发并应用双催化铁/脂肪酶体系用于苄基和脂肪族仲醇的动态动力学拆分。对 Knölker 型铁配合物的详细研究表明，醇的氢自动转移可以在温和的反应条件下进行，并允许与酶促拆分相结合。不同的外消旋醇可以有效地转化为手性乙酸酯，产率高，对映选择性好。
