Song Jibin, Hu Hao, Jian Chao, Wu Kaichun, Chen Xiaoyuan
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health , Bethesda, Maryland 20892, United States.
Sate Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University , Xi'an, China.
ACS Appl Mater Interfaces. 2016 Oct 19;8(41):27523-27529. doi: 10.1021/acsami.6b09104. Epub 2016 Oct 5.
Esophageal cancer is one of the six most common cancers in the world, constituting ∼7% of the gastrointestinal cancers. Esophageal stents can be inserted into the esophagus to open the pathway as a palliative treatment for advanced esophageal cancer. For the treatment of esophageal cancer, a series of anticancer drug-loaded stents such as paclitaxel or 5-fluorouracil/esophageal stent combinations have been prepared by covering a nitinol stent with a polymer or hydrogel shell. For the first time, we developed a gold nanoshell (AuNS)-coated stent with high photothermal efficiency and used in the repetitive photothermal therapy of esophageal cancer. The functionalized stent was prepared by using surface-coated polydopamine as the Au anchor and template. The thickness of the AuNS can be easily adjusted by controlling the reaction time and amount of Au. The AuNS-coated stent efficiently increased the temperature of pork and porcine intestines irradiated with a near-infrared (NIR) laser. The deep penetration of the NIR laser and excellent stability of the stent provide opportunity for the clinical applications of the newly functionalized stent. In vitro toxicity experiments showed excellent biocompatibility and safety of this device. Compared with bare metal stent, AuNS-modified stent exhibits great potential to open the duct passageway and suppress tumor growth in future clinical applications.
食管癌是世界上六种最常见的癌症之一，约占胃肠道癌症的7%。食管支架可插入食管以开通通道，作为晚期食管癌的姑息治疗方法。为了治疗食管癌，人们通过用聚合物或水凝胶壳覆盖镍钛诺支架，制备了一系列载有抗癌药物的支架，如紫杉醇或5-氟尿嘧啶/食管支架组合。我们首次开发了一种具有高光热效率的金纳米壳（AuNS）涂层支架，并将其用于食管癌的重复光热治疗。通过使用表面包覆的聚多巴胺作为金的锚定物和模板制备了功能化支架。通过控制金的反应时间和用量，可以轻松调节AuNS的厚度。AuNS涂层支架能有效提高近红外（NIR）激光照射下猪肉和猪肠的温度。NIR激光的深度穿透和支架的优异稳定性为这种新功能化支架的临床应用提供了机会。体外毒性实验表明该装置具有优异的生物相容性和安全性。与裸金属支架相比，AuNS修饰的支架在未来临床应用中具有打开导管通道和抑制肿瘤生长的巨大潜力。
