Hasiso Temesgen Yohannes, Desse Tigestu Alemu
School of Pharmacy, Jimma University, Jimma, Ethiopia.
Clinical Pharmacy Department, School of Pharmacy, Jimma University, Jimma, Ethiopia.
PLoS One. 2016 Sep 29;11(9):e0163040. doi: 10.1371/journal.pone.0163040. eCollection 2016.
Non adherence of epileptic patients to antiepileptic medication often leads to an increased risk of seizures and worsening of disease, death and increased health care costs.
to assess adherence to treatment and factors affecting adherence of epileptic patients at Yirgalem General Hospital, Southern Ethiopia.
We conducted a cross-sectional study on epileptic patients from February 9 to 22, 2015. Data were collected from patients ≥18 years old. Adherence was measured using the eight-item Morisky's medication adherence scale. All consecutive patients coming to epilepsy clinic during the study period were interviewed until the calculated sample size (210) was obtained. We collected patient demographics, perception about epilepsy and adherence to medication(s). We used chi-square tests and a binary logistic regression model for statistical analysis. Statistical significance was considered at P<0.05.
out of a total of 210 participants, 194 were willing to participate and were studied. Of the 194 participants, 109 (56.2%) were males. The mean age of the participants was 33.62±11.44 years; range 18 to 66 years. The majority, 123(63.41%), of the participants were taking two antiepileptic medications. Sixty two (32%) of the participants were adherent to their treatment. The most common reported reasons for non-adherence were forgetfulness 49(75.4%) and run out of pills 7(10.8%). Factors that affect medication adherence are epilepsy treatment for <1 year (P = 0.011), epilepsy treatment for 1-3 years (P = 0.002), epilepsy treatment for 3-5 years (P = 0.007), being married (P = 0.006), grade 9-12 education (P = 0.028), college or university education (P = 0.002) and absence of co-morbidity (P = 0.008).
The rate of adherence observed in this study was low. The most common reason for non- adherence was forgetfulness. Therefore, the hospital should devise strategies to improve adherence of epileptic patients at the hospital.
癫痫患者不坚持服用抗癫痫药物往往会导致癫痫发作风险增加、病情恶化、死亡以及医疗保健成本上升。
评估埃塞俄比亚南部伊尔加莱姆综合医院癫痫患者的治疗依从性及影响依从性的因素。
我们于2015年2月9日至22日对癫痫患者进行了一项横断面研究。数据收集自18岁及以上的患者。使用八项Morisky药物依从性量表来测量依从性。在研究期间，对所有前来癫痫门诊的连续患者进行访谈，直至获得计算出的样本量（210例）。我们收集了患者的人口统计学信息、对癫痫的认知以及药物治疗依从性。我们使用卡方检验和二元逻辑回归模型进行统计分析。P<0.05时认为具有统计学意义。
在总共210名参与者中，194名愿意参与并接受研究。在这194名参与者中，109名（56.2%）为男性。参与者的平均年龄为33.62±11.44岁；年龄范围为18至66岁。大多数参与者，即123名（63.41%），正在服用两种抗癫痫药物。62名（32%）参与者坚持治疗。报告的最常见不依从原因是遗忘，有49名（75.4%），以及药物用完，有7名（10.8%）。影响药物依从性的因素包括癫痫治疗时间<1年（P = 0.011）、癫痫治疗1 - 3年（P = 0.002）、癫痫治疗3 - 5年（P = 0.007）、已婚（P = 0.006）、九年级至十二年级教育程度（P = 0.028）、大专或大学教育程度（P = 0.002）以及无合并症（P = 0.008）。
本研究中观察到的依从率较低。最常见的不依从原因是遗忘。因此，医院应制定策略以提高该医院癫痫患者的依从性。
