Abd Wahab Enas S, Al Omar Muaed, Altabakha Moawia M A M
Department of Pharmacy, Neuro Spinal Hospital, Dubai, United Arab Emirates.
Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.
J Pharm Bioallied Sci. 2020 Oct-Dec;12(4):499-507. doi: 10.4103/jpbs.JPBS_367_19. Epub 2020 Oct 8.
Adherence to antiepileptic drugs (AEDs) is an integral component of epilepsy management. There are no previous data in the United Arab Emirates (UAE).
The aim of this study was to assess the prevalence of AED adherence among patients attending the Neuro Spinal Hospital in UAE and to identify the predictors of nonadherence.
A cross-sectional study was conducted between April 2018 and May 2019, and included consecutive patients with epileptic who were receiving AEDs for at least 6 months. A validated interviewer-administered questionnaire was used. Adherence was assessed by four-item Morisky's Medication Adherence Scale with a score between 0 and 4. Patients were considered adherent or nonadherent for a score of zero, or 1 and more, respectively. Chi-square test, binary, and multiple logistic regression analysis were used.
The study included 315 respondents, 70.8% ( = 223) were adherent, the rest were nonadherent. The most common factor affecting adherence was forgetfulness. Lower education level and having a seizure within the last 6 months were significant risk of nonadherence (odds ratio [OR] 95% confidence interval [CI] = 2.6 (1.2-5.8) and 2.5 (1.3-5.2), respectively), whereas levetiracetam intake reduces the risk of nonadherence (OR: 0.5 [0.2-0.9]).
The prevalence of AED adherence was 70.8%. Education level and having a seizure in the last 6 months were significant predictors of nonadherence, whereas levetiracetam intake reduces the risk of nonadherence.
坚持服用抗癫痫药物（AEDs）是癫痫管理的一个重要组成部分。阿拉伯联合酋长国（阿联酋）此前没有相关数据。
本研究的目的是评估阿联酋神经脊髓医院患者中AEDs依从性的患病率，并确定不依从的预测因素。
2018年4月至2019年5月进行了一项横断面研究，纳入了连续接受AEDs治疗至少6个月的癫痫患者。使用经过验证的由访谈者实施的问卷。通过四项Morisky药物依从性量表评估依从性，分数在0至4分之间。得分分别为零或1分及以上的患者被视为依从或不依从。采用卡方检验、二元和多元逻辑回归分析。
该研究包括315名受访者，70.8%（n = 223）为依从者，其余为不依从者。影响依从性的最常见因素是遗忘。教育水平较低和在过去6个月内有癫痫发作是不依从的显著风险因素（优势比[OR] 95%置信区间[CI]分别为2.6（1.2 - 5.8）和2.5（1.3 - 5.2）），而服用左乙拉西坦可降低不依从的风险（OR：0.5 [0.2 - 0.9]）。
AEDs依从性的患病率为70.8%。教育水平和过去6个月内有癫痫发作是不依从的显著预测因素，而服用左乙拉西坦可降低不依从的风险。
