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[一名患有腹泻、轻瘫和缄默症的4岁女童]

[A 4-year-old girl with diarrhoea, paresis and mutism].

作者信息

Engan Mette, Bjørlykke John Asle, Moen Gunnar, Lund Kjetil Børve, Njølstad Gro

机构信息

Barneklinikken Haukeland universitetssykehus.

Seksjon for barn Radiologisk avdeling Haukeland universitetssykehus.

出版信息

Tidsskr Nor Laegeforen. 2016 Sep 27;136(17):1458-60. doi: 10.4045/tidsskr.16.0070. eCollection 2016 Sep.

Abstract

BACKGROUND Rotavirus is a common cause of gastroenteritis in children. Neurological manifestations associated with rotavirus infections are well described and range from benign afebrile convulsions to lethal encephalopathy or encephalitis.CASE PRESENTATION We present an uncommon neurological manifestation in a Caucasian child in the course of a rotavirus infection. A 4-year old girl presented with mutism, hypotonia and reduced consciousness. Magnetic resonance imaging revealed diffusion abnormalities in the splenium corpus callosum and bilaterally in the nuclei dentate in the cerebellum. She was diagnosed with rotavirus cerebellitis.INTERPRETATION Her clinical symptoms and the magnetic resonance imaging abnormalities were uncommon and previously described in only a few Caucasian children. The outcome has varied, and some children have shown long term neurological sequela. Treatment with immunoglobulins and corticosteroids has been used in similar cases, but there is no established treatment for this condition.

摘要

背景

轮状病毒是儿童肠胃炎的常见病因。与轮状病毒感染相关的神经学表现已有详尽描述,范围从良性无热惊厥到致命性脑病或脑炎。

病例报告

我们报告一名白人儿童在轮状病毒感染过程中出现的一种罕见神经学表现。一名4岁女孩表现为缄默症、肌张力减退和意识减退。磁共振成像显示胼胝体压部及双侧小脑齿状核存在弥散异常。她被诊断为轮状病毒小脑炎。

解读

她的临床症状和磁共振成像异常情况较为罕见,此前仅在少数白人儿童中有所描述。预后情况各异,一些儿童出现了长期神经后遗症。类似病例曾使用免疫球蛋白和皮质类固醇进行治疗,但针对这种病症尚无既定的治疗方法。

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