Women's and Children's Program, Monash Medical Centre, Clayton, Victoria, Australia.
Pediatr Neurol. 2012 Jan;46(1):48-50. doi: 10.1016/j.pediatrneurol.2011.10.002.
Rotavirus infection is a significant cause of childhood morbidity and mortality worldwide. Although infection primarily causes gastroenteritis and dehydration, systemic signs and neurologic manifestations in rotavirus infection are widely recognized. The pathophysiologic origins of neurologic signs in rotavirus infection remain incompletely understood. We present a 4-year-old girl with clinical features of severe cerebellitis in association with abnormalities detected on magnetic resonance imaging. Rotavirus nucleic acid was demonstrated in both serum and cerebrospinal fluid. Severe neurologic sequelae remain after 2 years of follow-up. This report adds further evidence supporting a direct role for rotavirus in neurologic illness.
轮状病毒感染是全球儿童发病率和死亡率的重要原因。虽然感染主要引起肠胃炎和脱水，但轮状病毒感染的全身症状和神经表现已被广泛认识。轮状病毒感染导致神经症状的病理生理起源仍不完全清楚。我们报告了一例 4 岁女孩，其临床表现为严重小脑炎，磁共振成像检查发现异常。血清和脑脊液中均检测到轮状病毒核酸。随访 2 年后仍存在严重的神经后遗症。本报告提供了更多证据支持轮状病毒在神经疾病中的直接作用。
