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建立和维护一个可运作的生物和物理回顾性剂量测定网络的协调过程:应用于欧洲中子剂量测定研究合作网络(RENEB)的质量保证和质量管理

The harmonization process to set up and maintain an operational biological and physical retrospective dosimetry network: QA QM applied to the RENEB network.

作者信息

Gregoire Eric, Ainsbury Liz, Barrios Leonardo, Bassinet Céline, Fattibene Paola, Kulka Ulrike, Oestreicher Ursula, Pantelias Gabriel, Terzoudi Georgia, Trompier Francois, Voisin Philippe, Vral Anne, Wojcik Andrzej, Roy Laurence

机构信息

a Institut de Radioprotection et de Sûreté Nucléaire , Fontenay-Aux-Roses , France.

b Public Health England, CRCE, Chilton , Didcot, Oxon , UK.

出版信息

Int J Radiat Biol. 2017 Jan;93(1):81-86. doi: 10.1080/09553002.2016.1206232. Epub 2016 Aug 11.

DOI:10.1080/09553002.2016.1206232
PMID:27686284
Abstract

PURPOSE

The European Network of Biological and Physical Retrospective Dosimetry 'RENEB' has contributed to European radiation emergency preparedness. To give homogeneous dose estimation results, RENEB partners must harmonize their processes.

MATERIALS AND METHODS

A first inter-comparison focused on biological and physical dosimetry was used to detect the outliers in terms of dose estimation. Subsequently, trainings were organized to improve both tools dose estimation. A second inter-comparison was performed to validate training efficiency. Simultaneously, based on ISO standards, a QA&QM manual on all dosimetry assays was produced which states a common basis and harmonized procedures for each assay. The evaluation of the agreement of RENEB partners to follow the QA&QM manual was performed through a questionnaire. The integration of new members into the network was carried out in the same way, whatever the assays.

RESULTS

The training courses on biological and physical dosimetry were judged to be successful because most of the RENEB members' dose estimates improved in the second inter-comparison. The QA&QM manual describes the consensus for the minimum requirements and the performance criteria for both dosimetry assays. The questionnaire revealed that the whole network capacity currently can manage between 15 and 3800 samples once.

CONCLUSION

The methodology used to harmonize all dosimetry practice within the network RENEB was highly successful. The network is operational to manage a mass casualty radiation accident for immediate dose assessment.

摘要

目的

欧洲生物与物理回顾性剂量测定网络“RENEB”为欧洲辐射应急准备工作做出了贡献。为了给出统一的剂量估算结果,RENEB的合作伙伴必须使其流程协调一致。

材料与方法

首次比对聚焦于生物和物理剂量测定,用于检测剂量估算方面的异常值。随后,组织了培训以改进这两种工具的剂量估算。进行了第二次比对以验证培训效果。同时,基于ISO标准,编写了一份关于所有剂量测定分析的质量保证与质量管理手册,该手册为每种分析规定了共同的基础和协调一致的程序。通过问卷调查对RENEB合作伙伴遵守质量保证与质量管理手册的情况进行了评估。无论采用何种分析方法,新成员加入网络的方式都是相同的。

结果

生物和物理剂量测定培训课程被认为是成功的,因为在第二次比对中,大多数RENEB成员的剂量估算有所改进。质量保证与质量管理手册描述了两种剂量测定分析的最低要求和性能标准的共识。问卷调查显示,目前整个网络一次可处理15至3800个样本。

结论

RENEB网络中用于协调所有剂量测定实践的方法非常成功。该网络可用于管理大规模伤亡辐射事故,以进行即时剂量评估。

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