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阻塞性睡眠呼吸暂停综合征严重程度对端粒长度的影响。

The effect of the severity of obstructive sleep apnea syndrome on telomere length.

作者信息

Tempaku Priscila Farias, Mazzotti Diego Robles, Hirotsu Camila, Andersen Monica Levy, Xavier Gabriela, Maurya Pawan Kumar, Rizzo Lucas Bortolotto, Brietzke Elisa, Belangero Sintia Iole, Bittencourt Lia, Tufik Sergio

机构信息

Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.

Laboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.

出版信息

Oncotarget. 2016 Oct 25;7(43):69216-69224. doi: 10.18632/oncotarget.12293.

DOI:10.18632/oncotarget.12293
PMID:27690344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5342471/
Abstract

Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction. All individuals were subjected to one full-night polysomnography. LTL was significantly shorter in OSAS patients compared to controls. The results showed negative correlations between LTL and the following variables: apnea-hypopnea index, respiratory disturbance index, desaturation index and wake after sleep onset. LTL was positively correlated with sleep efficiency, total sleep time, basal, minimum and maximum oxygen saturation. Lastly, it was observed that OSAS severity was associated with shorter LTL even after adjusting for sex, age, years of schooling, body mass index, diabetes, stroke and heart attack. In conclusion, our study indicates the presence of an association between LTL and OSAS and a significant impact of severity of OSAS in telomeres shortening.

摘要

衰老与阻塞性睡眠呼吸暂停综合征（OSAS）患病率的增加以及端粒缩短有关。已知与OSAS相关的因素是可导致细胞衰老加速的刺激因素。因此，本研究旨在比较OSAS患者与对照组之间的白细胞端粒长度（LTL），并验证LTL与睡眠参数之间的相关性。我们使用从EPISONO的928名个体中提取的DNA，通过定量实时聚合酶链反应测量LTL。所有个体均接受了一整晚的多导睡眠图检查。与对照组相比，OSAS患者的LTL明显更短。结果显示LTL与以下变量之间存在负相关：呼吸暂停低通气指数、呼吸紊乱指数、去饱和指数和睡眠开始后的觉醒。LTL与睡眠效率、总睡眠时间、基础、最低和最高血氧饱和度呈正相关。最后，观察到即使在调整了性别、年龄、受教育年限、体重指数、糖尿病、中风和心脏病发作后，OSAS严重程度仍与较短的LTL相关。总之，我们的研究表明LTL与OSAS之间存在关联，且OSAS严重程度对端粒缩短有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26f/5342471/c2d3df9222f8/oncotarget-07-69216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26f/5342471/8252d31cb8e5/oncotarget-07-69216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26f/5342471/c2d3df9222f8/oncotarget-07-69216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26f/5342471/8252d31cb8e5/oncotarget-07-69216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e26f/5342471/c2d3df9222f8/oncotarget-07-69216-g002.jpg

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