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未服用药物的儿科强迫症患者潜在决策过程受到干扰。

Disrupted latent decision processes in medication-free pediatric OCD patients.

作者信息

Erhan Ceyla, Bulut Gresa Çarkaxhiu, Gökçe Sebla, Ozbas Duru, Turkakin Esin, Dursun Onur Burak, Yazgan Yanki, Balcı Fuat

机构信息

Department of Psychology, Koç University, İstanbul, Turkey.

Child and Adolescent Psychiatry, Muş State Hospital, Muş, Turkey.

出版信息

J Affect Disord. 2017 Jan 1;207:32-37. doi: 10.1016/j.jad.2016.09.011. Epub 2016 Sep 20.

DOI:10.1016/j.jad.2016.09.011
PMID:27690351
Abstract

BACKGROUND

Decision-making in Obsessive Compulsive Disorder has typically been investigated in the adult population. Computational approaches have recently started to get integrated into these studies. However, decision-making research in pediatric OCD populations is scarce.

METHODS

We investigated latent decision processes in 21 medication-free pediatric OCD patients and 23 healthy control participants. We hypothesized that OCD patients would be more cautious and less efficient in evidence accumulation than controls in a two alternative forced choice (2AFC) task.

RESULTS

Pediatric OCD patients were less efficient than controls in accumulating perceptual evidence and showed a tendency to be more cautious. In comparison to post-correct decisions, OCD patients increased decision thresholds after erroneous decisions, whereas healthy controls decreased decision thresholds. These changes were coupled with weaker evidence accumulation after errors in both groups.

LIMITATIONS

The small sample size limited the power of the study.

CONCLUSIONS

Our results demonstrate poorer decision-making performance in pediatric OCD patients at the level of latent processes, specifically in terms of evidence accumulation.

摘要

背景

强迫症的决策过程通常在成年人群体中进行研究。计算方法最近开始被纳入这些研究。然而,儿科强迫症患者群体的决策研究却很匮乏。

方法

我们调查了21名未服用药物的儿科强迫症患者和23名健康对照参与者的潜在决策过程。我们假设在二选一强迫选择(2AFC)任务中,强迫症患者在证据积累方面会比对照组更加谨慎且效率更低。

结果

儿科强迫症患者在积累感知证据方面比对照组效率更低,并且表现出更谨慎的倾向。与正确决策后相比,强迫症患者在错误决策后提高了决策阈值,而健康对照者则降低了决策阈值。两组在错误后证据积累都变弱,这些变化与之相关。

局限性

样本量小限制了研究的效力。

结论

我们的结果表明,儿科强迫症患者在潜在过程层面的决策表现较差,特别是在证据积累方面。

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