Salonen J T, Happonen P, Salonen R, Korhonen H, Nissinen A, Puska P, Tuomilehto J, Vartiainen E
Department of Community Health, University of Kuopio, Finland.
Prev Med. 1987 Sep;16(5):647-58. doi: 10.1016/0091-7435(87)90048-x.
The interdependence of the associations of physical activity, smoking, and consumption of alcohol and coffee with serum high-density lipoprotein and non-high-density lipoprotein cholesterol concentrations was studied in 9,347 persons ages 25-64 years from east and southwest Finland. In covariance analyses with corrections for age, body mass index, saturated fat index, and fasting time, the mean adjusted serum high-density lipoprotein to non-high-density lipoprotein cholesterol ratio was high among physically active male non-smokers but not among smokers (P = 0.024 for two-way interaction). The cholesterol ratio was lower among both men (P = 0.010 for two-way interaction) and women (P = 0.030 for two-way interaction) reporting no or very little use of alcohol, and this association was stronger among smokers and women with high coffee consumption (P less than 0.001 for two-way interaction). Our data suggest that the elevating effect of regular physical exercise on serum high-density lipoprotein cholesterol may be absent in smokers, whereas that of alcohol is greater in smokers than nonsmokers. High coffee consumption associates with decreased serum high-density lipoprotein cholesterol levels in smokers but increased levels in non-smokers.
对来自芬兰东部和西南部的9347名年龄在25至64岁之间的人群，研究了身体活动、吸烟、饮酒和喝咖啡与血清高密度脂蛋白及非高密度脂蛋白胆固醇浓度之间关联的相互依赖性。在对年龄、体重指数、饱和脂肪指数和禁食时间进行校正的协方差分析中，身体活动的男性非吸烟者的平均校正血清高密度脂蛋白与非高密度脂蛋白胆固醇比值较高，而吸烟者中则不然（双向交互作用P = 0.024）。报告不饮酒或极少饮酒的男性（双向交互作用P = 0.010）和女性（双向交互作用P = 0.030）的胆固醇比值较低，且这种关联在吸烟者和咖啡摄入量高的女性中更强（双向交互作用P < 0.001）。我们的数据表明，吸烟者中定期体育锻炼对血清高密度脂蛋白胆固醇的升高作用可能不存在，而饮酒对吸烟者的作用比对非吸烟者更大。大量喝咖啡与吸烟者血清高密度脂蛋白胆固醇水平降低相关，但与非吸烟者血清高密度脂蛋白胆固醇水平升高相关。
