Zhong Qiao-Qing, Wang Xiang, Li Yun-Feng, Peng Li-Jun, Jiang Zhi-Sheng
1 Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
2 Post-doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China.
Exp Biol Med (Maywood). 2017 Feb;242(3):250-257. doi: 10.1177/1535370216672747. Epub 2016 Oct 4.
Secretory leukocyte protease inhibitor (SLPI), a serine protease inhibitor, which was most commonly examined in mucosal fluids such as saliva, is a versatile molecule and plays non-redundant roles. In addition to its anti-protease activity, SLPI has been shown to express anti-bacterial, anti-viral, anti-fungal, and anti-inflammatory properties as well as participating in innate and adaptive immune responses, most of which has been well documented. Recently, it is reported that SLPI is expressed in adipocytes and adipose tissue where it could play an important feedback role in the resolution of inflammation. Furthermore, circulating SLPI has been shown to correlate with progressive metabolic dysfunction. Moreover, adenoviral gene delivery of elafin and SLPI attenuates nuclear factor-κB-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli. This review contributes to unraveling the protective role of SLPI in obesity-related atherosclerosis development, and the potential role in preventing arterial plaque rupture.
分泌型白细胞蛋白酶抑制剂（SLPI）是一种丝氨酸蛋白酶抑制剂，最常在唾液等黏膜液中检测到，它是一种多功能分子，发挥着不可替代的作用。除了具有抗蛋白酶活性外，SLPI还表现出抗菌、抗病毒、抗真菌和抗炎特性，并且参与先天性和适应性免疫反应，其中大部分已有充分记录。最近有报道称，SLPI在脂肪细胞和脂肪组织中表达，在炎症消退过程中可能发挥重要的反馈作用。此外，循环中的SLPI已被证明与进行性代谢功能障碍相关。此外，通过腺病毒基因递送弹性蛋白酶和SLPI可减弱人内皮细胞和巨噬细胞对致动脉粥样硬化刺激的核因子-κB依赖性炎症反应。本综述有助于阐明SLPI在肥胖相关动脉粥样硬化发展中的保护作用以及在预防动脉斑块破裂中的潜在作用。
