Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong 515041, China.
Department of Sports, Shantou University Medical College, Shantou, Guangdong 515041, China.
Sci Rep. 2016 Oct 4;6:34689. doi: 10.1038/srep34689.
Sleep habits are associated with stroke in western populations, but this relation has been rarely investigated in China. Moreover, the differences among stroke subtypes remain unclear. This study aimed to explore the associations of total stroke, including ischemic and hemorrhagic type, with sleep habits of a population in southern China. We performed a case-control study in patients admitted to the hospital with first stroke and community control subjects. A total of 333 patients (n = 223, 67.0%, with ischemic stroke; n = 110, 23.0%, with hemorrhagic stroke) and 547 controls were enrolled in the study. Participants completed a structured questionnaire to identify sleep habits and other stroke risk factors. Least absolute shrinkage and selection operator (Lasso) and multiple logistic regression were performed to identify risk factors of disease. Incidence of stroke, and its subtypes, was significantly associated with snorting/gasping, snoring, sleep duration, and daytime napping. Snorting/gasping was identified as an important risk factor in the Lasso logistic regression model (Lasso' β = 0.84), and the result was proven to be robust. This study showed the association between stroke and sleep habits in the southern Chinese population and might help in better detecting important sleep-related factors for stroke risk.
睡眠习惯与西方人群的中风有关，但这种关系在中国很少被研究。此外，中风亚型之间的差异仍不清楚。本研究旨在探讨中国南方人群中风（包括缺血性和出血性）与睡眠习惯的关系。我们对因首次中风住院的患者和社区对照者进行了病例对照研究。共纳入 333 名患者（n=223，67.0%为缺血性中风；n=110，23.0%为出血性中风）和 547 名对照者。参与者完成了一份结构化问卷，以确定睡眠习惯和其他中风危险因素。使用最小绝对收缩和选择算子（Lasso）和多变量逻辑回归来确定疾病的危险因素。中风及其亚型的发生率与打鼾/喘气、睡眠呼吸暂停、睡眠时间和白天小睡显著相关。Lasso 逻辑回归模型（Lasso'β=0.84）中确定打鼾/喘气是一个重要的危险因素，结果证明是稳健的。本研究显示了中国南方人群中风与睡眠习惯之间的关系，可能有助于更好地发现与中风风险相关的重要睡眠相关因素。
