Department of Family Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si 16995, Gyeonggi-do, Korea.
Int J Environ Res Public Health. 2020 Apr 13;17(8):2657. doi: 10.3390/ijerph17082657.
Serum high-sensitivity C-reactive protein (hsCRP) and serum uric acid (SUA) are biomarkers that predict chronic inflammation and cardiovascular dysfunction. Therefore, we aimed to investigate the association between sleep duration, hsCRP, and SUA in Korean women. Cross-sectional data from the Seventh Korea National Health and Nutrition Examination Survey was analyzed. The odds ratio (OR) and 95% confidence intervals (CIs) for an association between higher hsCRP (>2.0 mg/L) or higher SUA (>5.6 mg/dL) and sleep duration were calculated using multiple logistic regression analyses after adjusting for potential confounders. In total, 6151 women were included in the analysis. There was a U-shaped relationship between continuous sleep duration, hsCRP, and SUA. Compared to those who slept for 7-8 h, the ORs (95% CIs) for higher hsCRP were 1.43 (0.95-2.16) in short sleepers and 1.64 (1.09-2.48) in long sleepers after adjusting for confounders. Compared with those who slept for 7-8 h, the ORs (95% CIs) for higher SUA were 1.54 (1.04-2.26) in short sleepers and 1.94 (1.27-2.96) in long sleepers after adjusting for confounders. We found a U-shaped association between sleep duration, hsCRP, and SUA in Korean women. 7-8 h sleep was associated with lower level of hsCRP and SUA in Korean women.
血清高敏 C 反应蛋白（hsCRP）和血清尿酸（SUA）是预测慢性炎症和心血管功能障碍的生物标志物。因此，我们旨在研究韩国女性的睡眠时间、hsCRP 和 SUA 之间的关系。本研究分析了第七次韩国国家健康和营养检查调查的横断面数据。使用多因素逻辑回归分析，在校正了潜在混杂因素后，计算了 hsCRP（>2.0mg/L）或 SUA（>5.6mg/dL）较高与睡眠时间之间的比值比（OR）和 95%置信区间（CI）。共纳入 6151 名女性进行分析。连续睡眠时间、hsCRP 和 SUA 之间呈 U 形关系。与睡 7-8 小时的人相比，调整混杂因素后，短睡眠者 hsCRP 较高的 OR（95%CI）为 1.43（0.95-2.16），长睡眠者 hsCRP 较高的 OR（95%CI）为 1.64（1.09-2.48）。与睡 7-8 小时的人相比，调整混杂因素后，短睡眠者 SUA 较高的 OR（95%CI）为 1.54（1.04-2.26），长睡眠者 SUA 较高的 OR（95%CI）为 1.94（1.27-2.96）。我们发现韩国女性的睡眠时间、hsCRP 和 SUA 之间呈 U 形关系。7-8 小时的睡眠与韩国女性较低的 hsCRP 和 SUA 水平相关。
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