Baumgaertel Johanna, Haussmann Robert, Gruschwitz Antonia, Werner Annett, Osterrath Antje, Lange Jan, Donix Katharina L, Linn Jennifer, Donix Markus
1Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
3Department of Neuroradiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Aging Dis. 2016 Oct 1;7(5):553-560. doi: 10.14336/AD.2016.0305. eCollection 2016 Oct.
Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages. We wanted to investigate whether the years of formal education, a proxy measure for cognitive reserve, would influence hippocampal structure in Alzheimer's disease patients, and whether apolipoprotein Eε4 (APOE4) carrier status and a first-degree family history of the disease would change a possible association. Fifty-eight Alzheimer's disease patients underwent 3T magnetic resonance imaging. We applied a cortical unfolding approach to investigate individual subregions of the medial temporal lobe. Among patients homozygous for the APOE4 genotype or carrying both APOE4 and family history risks, lower education was associated with a thinner cortex in multiple medial temporal regions, including the hippocampus. Our data suggest that the years of formal education and genetic risks interact in their influence on hippocampal structure in Alzheimer's disease patients.
遗传和环境保护因素及风险在神经退行性疾病及其临床前期阶段调节大脑结构和功能。我们想研究受教育年限（认知储备的一种替代指标）是否会影响阿尔茨海默病患者的海马结构，以及载脂蛋白Eε4（APOE4）携带者状态和该病的一级家族史是否会改变这种可能的关联。58名阿尔茨海默病患者接受了3T磁共振成像检查。我们应用皮质展开方法来研究内侧颞叶的各个亚区域。在APOE4基因型纯合或同时携带APOE4和家族史风险的患者中，受教育程度较低与包括海马在内的多个内侧颞叶区域的皮质较薄有关。我们的数据表明，受教育年限和遗传风险在对阿尔茨海默病患者海马结构的影响中相互作用。
